Pdac cell models

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Mass Spectrometry (31)
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CHEBI ID

CHEBI:180628 (1)
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CHEBI:5320 (1)
CHEBI:180612 (1)
CHEBI:180611 (1)

Metabolite Name

P-Vinylbiphenyl (1)
Oxalic acid-guanidine (1/1) (1)
1,6-di-o-phosphonohex-2-ulofuranose (1)
Dibutyl terephthalate (1)
(R)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid (1)
L-Glutarylcarnitine (1)
4,4'-Methylenediphenol (1)
Dehydrofelodipine (1)
U-0126 (1)
Methyl 3,4,6-tri-O-acetyl-2-deoxy-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-thiohexopyranoside (1)
N'-[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-4-nitrobenzohydrazide (1)
1-(3-Isocyanatophenyl)-5-(methylsulfanyl)-1H-tetrazole (1)
Gly-Met-Val (1)
3-Aminopentanoic acid (1)
2-[3-Carboxy-3-(methylammonio)propyl]-L-histidine (1)
Ala-Ala-Gly-Ala (1)
Ala-Gln-Ala (1)
4-Dedimethylamine-4-oxo-anhydro-7-Cl-tetracycline (1)
Trp-Ser-Pro (1)
Gly-Gly-Thr-Tyr (1)
4-Hydroxy-5-phenyl-1,3-oxazinan-2-one (1)
3,4-Methylenedioxybenzyl methyl ketoximine (1)
Methyl 4,4,4-trifluoro-3-hydroxy-3-methoxybutanoate (1)
Thr-Tyr-Gly-Gly (1)
Gentioflavine (1)
Asp-Thr-His-Gly (1)
Acetic acid-1-(2-ethoxyethoxy)ethan-1-ol (1/1) (1)
Terestigmine (1)
Glu-Cys-Gly (1)
2-Deoxy-2,3-didehydro-N-glycoloylneuraminic acid (1)

First Public Date

2026 (87)
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2020 (21)
2022 (16)
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2014 (10)
2019 (7)
2018 (3)
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2015 (1)

Study type

Transcription profiling by array (17)
RNA-seq of coding RNA (7)
ChIP-seq (3)
Comparative genomic hybridization by array (2)
RNA-seq of coding RNA from single cells (2)
Unknown experiment type (1)
Methylation profiling by array (1)

Release Date

2025 (135)
2024 (109)
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2019 (59)
2018 (41)
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2013 (12)
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2009 (1)

Lab affiliation

Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (2)
General Manager of PROMEC Department of Clinical and Molecular Medicine +4773598508 +4772573342 Laboratoriesenteret, 231.04.008, Øya, Erling Skjalgssons gate 1 Norway (2)
Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) (2)
Acting Head of Proteomics (1)
Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS) School of Life Sciences Technical University Munich (TUM) Gregor-Mendel-Straße 4 85354 Freising GERMANY Bavarian Center for Biomolecular Mass Spectrometry Technische Universität München Gregor-Mendel-Straße 4 85354 Freising DEUTSCHLAND / GERMANY (1)
Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS) Technical University Munich (TUM) Gregor-Mendel-Straße 4 85354 Freising GERMANY (1)
Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Copenhagen, Denmark (1)
Cancer Pharmacology Lab, Fondazione Pisana per la Scienza, San Giuliano, Pisa, Italy (1)
Centre for Genomics and Computational Biology Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ Tel: +44 (0)20 7882 8266 | Fax: +44 (0)20 7882 3891 | Email: p.cutillas@qmul.ac.uk (1)
Core Unit Proteomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany. (1)
Daglig leder, PROMEC Institutt for klinisk og molekylær medisin 73598508 72573342 Laboratoriesenteret, 231.04.008, Øya, Erling Skjalgssons gate 1 (1)
Daglig leder, PROMEC Institutt for klinisk og molekylær medisin lars.hagen@ntnu.no 73598508 72573342 Laboratoriesenteret, 231.04.008, Øya, Erling Skjalgssons gate 1 (1)
Daglig leder, PROMEC Institutt for klinisk og molekylær medisin lars.hagen@ntnu.no 73598508 72573342 Laboratoriesenteret, 231.04.008, Øya, Erling Skjalgssons gate 1 Norway (1)
Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China (1)
Department of Pathology, Institute of Systems Biomedicine, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China (1)
Department of Pharmaceutical Sciences, School of Pharmacy, University at Buffalo, Buffalo, New York, United States (1)
Department of Pharmacology, Lineberger Comprehensive Cancer Center, UNC Chapel Hill (1)
Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, United States Department of Microbiology and Immunology, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, United States (1)
Department of Translational Medicine (DiMeT), Center for Translational Research on Autoimmune & Allergic Diseases - CAAD, University of Piemonte Orientale, Corso Trieste 15/A, 28100, Novara, Italy (1)
Dept. of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill (1)
Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA Department of Radiation Oncology, Brigham and Women’s Hospital, Boston, MA 02115 (1)
Full Professor of Systems Biology and Director of Computational Modelling Systems Biology Ireland, University College Dublin, Dublin, Ireland. Conway Institute of Biomolecular & Biomedical Research,University College Dublin, Dublin, Ireland. School of Medicine and Medical Science, University College Dublin, Dublin, Ireland. Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA (1)
Laboratory of Digestive Oncology, Department of Oncology, KU Leuven & University Hospitals Leuven, Geb. Onderwijs & Navorsing 4, room 07.465, Herestraat 49, Bus 603, B 3000, Leuven, Belgium (1)
Lineberger Comprehensive Cancer Center Department of Pharmacology UNC Chapel Hill Chapel Hill NC USA (1)
OmicVision Biosciences ApS (1)
Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, 60611, USA Division of Hematology-Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA (1)
Sanford Burnham Prebys (1)
The University of Melbourne (1)

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Human Pancreatic Ductal Adenocarcinoma (PDAC), LC-MS/MS

The aim of the study was to characterize a common molecular mechanism for paclitaxel resistance in Patu-T and Suit-2.028 PDAC cell lines. Despite the ATP-binding cassette (ABC) trasnsporters were already shown to be involved in various chemo-resistant forms of cancers but not in PDAC, the most likel...

ORGANISM(S): Homo sapiens (Human)

2024-01-26 | PXD040930 | Pride

Expression profiling of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all common cancers, but divergent outcomes are apparent between patients. To delineate the intertumor heterogeneity that contributes to this, we aimed to identify clinically distinct gene expression-based subgroups. From a cohort of ...

ORGANISM(S): Homo sapiens

2020-01-25 | E-MTAB-6830 | biostudies-arrayexpress

Genome-wide map of GATA6 DNA binding in human PDAC cells

By studying a mouse model, as well as human tumors samples and cell lines, we have revealed a tumor suppressive role for Gata6 in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In order to understand the mechanism underlying such tumor suppressive function, we analyzed the genome-wide ...

ORGANISM(S): Homo sapiens

2015-02-03 | E-GEOD-47535 | biostudies-arrayexpress

Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various re...

ORGANISM(S): Mus musculus (Mouse)

2024-12-18 | PXD057795 | Pride

Murine pdac tumor

Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma

ORGANISM(S): Mus musculus (Mouse)

2024-12-18 | PXD057793 | Pride

Murine pdac cells

Stromal evolution of cancer-associated fibroblasts in PDAC GEMMs

With the advent of cancer immunotherapy, intense investigation has been focused on tumor-infiltrating immune cells. With only a fraction of patients responding to these new therapies, a better understanding of all elements of the tumor microenvironment (TME) that may influence therapeutic outcome is...

ORGANISM(S): Mus musculus

2019-10-31 | E-MTAB-8483 | biostudies-arrayexpress

Regulation of GLI underlies a role for BET bromodomains in pancreatic cancer growth and the tumor microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is extraordinarily chemoresistant and the abundant stromal content of these tumors contributes to the ineffective treatment of this disease. While the genetic alterations of PDAC have been well characterized, the epigenetic pathways regulating PDAC remain, fo...

ORGANISM(S): Homo sapiens

2016-09-08 | E-GEOD-55209 | biostudies-arrayexpress

Transcriptional dissection of pancreatic tumors engrafted in mice

Engraftment of primary pancreas ductal adenocarcinomas (PDAC) in mice to generate patient derived xenograft (PDX) models is a promising platform to for biological and therapeutic studies in this disease. However, these models are still incompletely characterized. Here, we measured the impact of the ...

ORGANISM(S): Homo sapiens

2014-04-22 | E-GEOD-51798 | biostudies-arrayexpress

Pancreatic ductal adenocarcinoma primary cultures enriched or not in cancer stem cells

RNA sequencing of pancreatic ductal adenocarcinoma (PDAC) primary cultures from five different patient-derived xenograft models grown either in adherent conditions selecting for non-CSCs or in CSC-enriching anchorage-independent sphere conditions. A and B are two biological duplicates, from the same...

ORGANISM(S): Homo sapiens

2015-11-01 | E-MTAB-3808 | biostudies-arrayexpress

Hierarchical clustering of PDAC cell lines

Hierarchical clustering of pancreatic cancer cell lines based on differentially regulated genes between mesenchymal and epithelial PDAC cells derived from primary tumours and metastases from KrasG12D-driven mouse models of pancreatic cancer.

ORGANISM(S): Mus musculus

2022-11-19 | E-MTAB-8173 | biostudies-arrayexpress

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