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GenomicsMyeloid-specific ablation of Pdcd1 alters fate comittment of tumor-associated macrophages and induces anti-tumor immunity
Myeloid-specific ablation of Pdcd1 alters fate comittment of tumor-associated macrophages and induces anti-tumor immunity
PRJNA849613 | ENA
TranscriptomicsMyeloid-specific ablation of Pdcd1 alters fate comittment of tumor-associated macrophages and induces anti-tumor immunity
We generated mice with conditional targeting of the Pdcd1 gene (encoding for PD-1) in myeloid cells (Pdcd1-2fl/flLysMCre). Pdcd1-2fl/flLysMCre mice had significantly diminished tumor growth. As revealed by RNA-seq, myeloid-specific Pdcd1 ablation was paralleled by generation of myeloid cells with mo...
ORGANISM(S): Mus musculus 
2022-10-26 | GSE206207 | GEO
UnknownModulation of PDCD1 exon 3 splicing.
Not available
S-EPMC6844568 | biostudies-literature
UnknownCBX4 promotes antitumor immunity by suppressing Pdcd1 expression in T cells.
Not available
S-EPMC10701776 | biostudies-literature
UnknownPDCD1 as a targetable immune checkpoint hub: therapeutic insights for ibrutinib-resistant CLL management.
Not available
S-EPMC12628378 | biostudies-literature
UnknownMachine Learning-Based Enhanced MRI Radiomics for PDCD1 Prognostication and Expression Prediction in Breast Cancer.
Not available
S-EPMC12663040 | biostudies-literature
TranscriptomicsSingle-cell transcriptome and TCR repertoire of PD-1 fate-mapped immune cells during cyclophosphamide and PD-1 blockade in syngeneic subcutaneous LLC tumor allografts
Processed single-cell datasets from Pdcd1-CreERT2 × Rosa26-tdTomato fate-mapping mice bearing subcutaneous LLC allografts and treated with CTX, anti-PD-1, or both. We provide count matrices, cell-level annotations, and per-cell TCR clonotypes; raw reads for transcriptome, sample-tag, and TCR librari...
ORGANISM(S): Mus musculus 
2026-03-11 | E-MTAB-15883 | biostudies-arrayexpress
UnknownAssociation between PDCD1 gene polymorphisms and psoriasis susceptibility in the Chinese population.
Not available
S-EPMC8596410 | biostudies-literature
UnknownIL-6/STAT3 Signaling Axis Enhances and Prolongs Pdcd1 Expression in Murine CD8 T Cells.
Not available
S-EPMC10103150 | biostudies-literature
UnknownPDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases.
Not available
S-EPMC7839592 | biostudies-literature
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