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TranscriptomicsPDGFR-alpha inhibits melanoma growth via CXCL10/IP-10 and miR-503. A multi-omics approach.
Cutaneous melanoma is the most aggressive skin cancer showing high mortality at advanced clinical stages. Platelet-Derived Growth Factor Receptor alpha (PDGFR-alpha) is known to strongly inhibit melanoma and endothelial cells proliferation, in vitro as well in vivo. PDGFR-alpha expression has been f...
ORGANISM(S): Homo sapiens 
2016-11-14 | E-MTAB-4261 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of imatinib-treated and untreated human Hematopoetic progenitors expressing the ETV6-PDGFRB oncogene
In order to investigate the mechanism whereby TEL-PDGF-beta (ETV6-PDGFRB) interferes with human hematopoietic progenitors proliferation and differentiation, we analyzed the gene expression response downstream this oncogene. CD34+ cells infected with lentivirus coding for TEL-PDGFRb were cultured for...
ORGANISM(S): Homo sapiens 
2012-04-09 | E-GEOD-28698 | biostudies-arrayexpress
TranscriptomicsPDGFR-alpha inhibits melanoma growth via CXCL10/IP-10 and miR-503. A multi-omics approach
Cutaneous melanoma is the most aggressive skin cancer showing high mortality at advanced clinical stages. Platelet-Derived Growth Factor Receptor alpha (PDGFR-alpha) is known to strongly inhibit melanoma and endothelial cell proliferation, in vitro as well in vivo. PDGFR-alpha expression has been fo...
ORGANISM(S): Homo sapiens 
2016-11-14 | E-MTAB-4266 | biostudies-arrayexpress
GenomicsDysregulated mesenchymal PDGFR-β drives kidney fibrosis
Dysregulated mesenchymal PDGFR-β drives kidney fibrosis
PRJNA577448 | ENA
TranscriptomicsDose-dependent dual roles of PDGF-BB–PDGFR-? in vascular remodeling and opposing effects of anti-PDGF drug-induced metastasis
Anti-PDGF agents are routinely used as a key component in front-line therapy for the treatment of various cancers. However, molecular mechanisms underlying their impact on vascular remodeling in relation to the dose issue remain poorly understood. Here we show that in high PDGF-BB-producing tumors, ...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-46564 | biostudies-arrayexpress
TranscriptomicsGene expression profiling regulated by PDGF in pBSMCs
To explore global molecular changes in smooth muscle in response to PDGFR activation, primary human bladder smooth muscle cells were treated with 1 nM PDGF-BB (hereafter PDGF) for 0, 4 or 24 h. Total RNA were prepared, and analyzed using expression profiling, and subjected to bioinformatic and funct...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-52488 | biostudies-arrayexpress
GenomicsPDGFR-alpha signaling in P0 cCFU-fibroblasts
PDGFR-alpha signaling in P0 cCFU-fibroblasts
PRJNA417976 | ENA
TranscriptomicsGene expression profiles of hepatic stellate cells isolated from Pdgfrb-knockout mice
Background & Aims: Rapid induction of beta-PDGF receptor (beta-PDGFR) is a core feature of hepatic stellate cell activation, the hallmark of liver fibrogenesis. However, biological consequences of the induction are not well characterized. We aimed to determine the involvement of beta-PDGFR-mediated ...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-52253 | biostudies-arrayexpress
TranscriptomicsConsequences of beta-PDGFR deletion on hepatic stellate cells during hepatic regeneration
Purpose: The goal of this study was to determine biological consequences during liver regeneration following partial hepatectomy in mice by next-generation sequencing. A particular interest was to compare mice with either a floxed b-PDGFR allele to mice that harbored a deletion of b-PDGFR in hepatic...
ORGANISM(S): Mus musculus 
2013-11-08 | E-GEOD-52234 | biostudies-arrayexpress
GenomicsSingle cell RNA sequencing to identify the PDGFR-β expressing lung cells
Single cell RNA sequencing to identify the PDGFR-β expressing lung cells
PRJNA765611 | ENA
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