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TranscriptomicsResveratrol Diet Aging (Heart, Liver, Muscle and Fat Tissue)
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others ha...
ORGANISM(S): Mus musculus 
2008-08-04 | E-GEOD-11845 | biostudies-arrayexpress
UnknownPrincipal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer's disease.
Not available
S-EPMC10338149 | biostudies-literature
TranscriptomicsEffects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Calorie restriction (CR) is the most robust non-genetic intervention to universally delay the onset of age-related diseases and extend mean and maximum lifespan. However, species, strain, sex, diet, age of onset, and level of CR are emerging as important variables to consider for a successful CR res...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-81959 | biostudies-arrayexpress
ProteomicsComparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype
Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently discovered that the strongest genetic risk factor for sporadic AD, apolipoprotein E epsilon 4 (APOE4), exacerbates synapse loss ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013753 | Pride
Alzheimer synapse apoe synaptoneurosome neurodegeneration 
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
ProteomicsProteomics of the brain and retina presents early hallmarks of Alzheimer’s disease
We performed proteomic profiling of the brain and retina in 3xTg-AD mouse model of Alzheimer's disease at one month of age to uncover early retinal signatures that may precede disease manifestations.
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD069995 | Pride
Alzheimer's disease  retina  brain  neurodegenerative diseases  3xtg-ad 
TranscriptomicsLiver Pharmacology and Xenobiotic Response Repertoire
A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology. We have used a ...
ORGANISM(S): Rattus norvegicus 
2008-03-28 | E-GEOD-8858 | biostudies-arrayexpress
UnknownDonepezil delays progression to AD in MCI subjects with depressive symptoms.
Not available
S-EPMC2697965 | biostudies-literature
GenomicsEpigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus
Comparison of transcriptome and histone acetylation in Camponotus floridanus minor scout brains following 45 day treatment with small molecule pharmacologicals. The goal of this study was to characterize the molecular changes in gene expression and histone modification caused by ad lib feeding small...
ORGANISM(S): Camponotus floridanus 
2015-12-10 | E-GEOD-69553 | biostudies-arrayexpress
UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
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