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UnknownStructural modeling and electron paramagnetic resonance spectroscopy of the human Na+/H+ exchanger isoform 1, NHE1.
Not available
S-EPMC3013023 | biostudies-literature
UnknownMCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells.
Not available
S-EPMC11112124 | biostudies-literature
UnknownThe human Na(+)/H(+) exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2.
Not available
S-EPMC4833948 | biostudies-literature
TranscriptomicsGene expression study of MCF7/tet-off clones expressing different HER2 isoforms
HER2 is a tyrosine kinase receptor causally involved in cancer. A subgroup of breast cancer patients with particularly poor clinical outcome expresses a heterogeneous collection of HER2 carboxy-terminal fragments (CTFs). However, since the CTFs lack the extracellular domain that drives dimerization ...
ORGANISM(S): Homo sapiens 
2015-04-25 | E-GEOD-68256 | biostudies-arrayexpress
ProteomicsDLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2
Polarized vesicular trafficking directs specific receptors and ion channels to cilia, but the underlying mechanisms are poorly understood. Here we describe a role for DLG1, a core component of the Scribble polarity complex, in regulating ciliary protein trafficking in kidney epithelial cells. Condit...
ORGANISM(S): Homo sapiens (Human) 
2024-05-14 | PXD051912 | Pride
Dlg1 Bioid2 Primary cilia 
ProteomicsDLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2
Polarized vesicular trafficking directs specific receptors and ion channels to cilia, but the underlying mechanisms are poorly understood. Here we describe a role for DLG1, a core component of the Scribble polarity complex, in regulating ciliary protein trafficking in kidney epithelial cells. Condit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD051906 | Pride
Dlg1 Bioid2 Primary cilia 
TranscriptomicsGene Expression in Peripheral Blood Leucocytes in Monozygotic Twins Discordant for Chronic Fatigue
Background. Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes. Methods. Cases were 44 individuals who were clinically ev...
ORGANISM(S): Homo sapiens 
2009-05-12 | E-GEOD-16059 | biostudies-arrayexpress
UnknownThe TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca2+-Independent Manner.
Not available
S-EPMC9323718 | biostudies-literature
ProteomicsO-glycan initiation directs distinct biological pathways and controls epithelial differentiation
Glycosylation is an abundant post-translational modification of both intracellular and extracellular proteins [1]. The majority of glycans are classified as N-linked chains, where the carbohydrate moiety is attached to asparagine residues, or O-linked chains, most commonly linked to a serine or thre...
ORGANISM(S): Homo sapiens (Human) 
2020-05-22 | PXD016618 | Pride
Differential glycoproteomics Polyomics Polypeptide galnac-transferase Tissue development 3d skin 
ProteomicsIntracellular pH regulates the ubiquitin-mediated degradation of the atypical MAP kinase ERK3
The atypical mitogen-activated protein kinase ERK3 is known for its instability and degradation via the ubiquitin-proteasome system (UPS). However, the specific environmental factors regulating ERK3 turnover have remained unclear. In this study, we demonstrate that intracellular pH (pHi) plays a cru...
ORGANISM(S): Homo sapiens (Human) 
2025-10-07 | PXD056239 | Pride
Map kinases  erk3  ph  protein stability 
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