Sort   by:  
 Page size 
MetabolomicsDietary restriction of lysine reduces pediatric obesity through enhancing Parabacteroides goldsteinii-produced 1,4-Methylimidazoleacetic acid

The influence of amino acid restriction on obesity may be related to the gut microbiome, but the role and mechanism of lysine restriction (LR) on pediatric obesity is largely undefined. Here, we found plasma lysine levels were significantly higher in obese patients than healthy controls of childr...

2025-09-18 | MTBLS13011 | MetaboLights
MetabolomicsMulti-omics association analysis reveals interactions between the oropharyngeal microbiome and the metabolome in pediatric patients with influenza A virus pneumonia.
Children are at high risk for influenza A virus (IAV) infections, which can develop into severe illnesses. However, little is known about interactions between the microbiome and respiratory tract metabolites and their impact on the development of IAV pneumonia in children. Using a combination of liq...
2024-09-25 | MTBLS4816 | MetaboLights
MetabolomicsUntargeted Lipidomics Profiling Provides Novel Insights into Pediatric Patients with Sepsis: An Exploratory Study

Background: The plasma lipidome has emerged as an important indicator for assessing host metabolic and immune status in sepsis. While previous studies have largely examined specific lipid class changes in adults sepsis, comprehensive investigations into plasma lipidomic alteratio...

2025-07-05 | MTBLS12058 | MetaboLights
MetabolomicsAssessment of plasma metabolomic biomarkers in various pediatric diseases

BACKGROUND: Metabolites that are direct read-outs of the functional status of cells, tissues, and organs can be more closely associated with phenotype compared to other omics profiles. Previous studies showed the analytical validity of metabolomic platforms and demonstrated a uti...

2024-05-14 | MTBLS948 | MetaboLights
MetabolomicsMultiomics analysis of neutrophils in SLE: insights from adult and pediatric disease

Neutrophils contribute to systemic lupus erythematosus (SLE) pathogenesis through ROS and NET production, and increased apoptotic debris which causes autoantibody production and immune complex formation. These processes drive inflammation and tissue damage. The aim of this study was to perform in...

2026-04-22 | MTBLS6259 | MetaboLights
MetabolomicsIntegrated multi-omics of feces, plasm aand urine can describe and differentiate pediatric active Crohn’s Disease from remission

Background

This study aimed to obtain a holistic view of remission in pediatric Crohn’s Disease (CD) by integrating six omics datasets from three anatomical compartments.


Methods

Patients with fecal calprotectin below 250 mg/kg were c...

2025-07-09 | MTBLS9877 | MetaboLights
MetabolomicsLinking gastrointestinal microbiota and metabolome dynamics to clinical outcomes in pediatric hematopoietic stem cell transplantation

BACKGROUND: Hematopoietic stem cell transplantation is a curative procedure for a variety of conditions. Despite major advances, a plethora of adverse clinical outcomes can develop post-transplantation including graft-versus-host disease and infections, which remain the major cau...

2022-05-11 | MTBLS4065 | MetaboLights
MetabolomicsDelayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations in the gut microbiome, i.e., the microorganisms and their genes within the gastrointestinal tract. Maturation of the infant immune system and gut microbiota occur in parallel; ...
2024-10-24 | MTBLS7919 | MetaboLights
MetabolomicsMechanisms of action of bile acids in pediatric gastroesophageal reflux: Exploration through non-targeted and targeted metabolomics methods

Purpose: To investigate the pathogenesis of pediatric bile reflux gastritis (BRG) using non-targeted and targeted metabolomics analyses of the changes and content differences of bile acids (BAs) in gastric juice. Methods: Data from 25 pediatric BRG patients treated at Jinhua Maternal and Child He...

2025-12-04 | MTBLS13450 | MetaboLights
MetabolomicsMulti-Omics Profiling Reveals Sex-Stratified Biomarkers Predicting Chronicity in Pediatric Primary Immune Thrombocytopenia

Primary immune thrombocytopenia (ITP) is recognized as an acquired autoimmune hemorrhagic disorder distinguished by diminished platelet counts. The efficacy of a sex-stratified multi-omics integrative analytical strategy for forecasting pediatric ITP chronicity was proposed and validated in this ...

2025-09-01 | MTBLS12920 | MetaboLights
Sort   by:  
 Page size