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TranscriptomicsNovel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas
The outcome for children with high-grade gliomas (HGG) remains dismal, with a two-year survival rate of only 10-30%. Approximately half of pediatric HGGs are diffuse intrinsic pontine glioma (DIPG), a brainstem tumor that arises almost exclusively in children. Genome-wide analyses of copy number i...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-46190 | biostudies-arrayexpress
TranscriptomicsIntegrated molecular genetic profiling of pediatric-high grade gliomas reveals key differences with adult disease
Purpose: To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). Patients and Methods: We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGG, including 7 diffuse intrinsic pontine gliomas, and 10 HGG cases ar...
ORGANISM(S): Homo sapiens 
2010-06-15 | E-GEOD-19578 | biostudies-arrayexpress
TranscriptomicsThe histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding histone H3 variant H3.3, in 60% of high-grade pediatric glioma cases. The median survival of this group of patients after diagnosis is ∼1 yr. Here we show that the levels of H3...
ORGANISM(S): Homo sapiens 
2014-09-20 | E-GEOD-61586 | biostudies-arrayexpress
GenomicsG207 and PVSRIPO treatment of medulloblastoma and pediatric high grade glioma
G207 and PVSRIPO treatment of medulloblastoma and pediatric high grade glioma
PRJNA978629 | ENA
TranscriptomicsAffymetrix SNP 250K array data for paediatric high grade gliomas
Alkylating agents are a frontline therapy for the treatment of several cancers including pediatric glioblastoma, a devastating lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways of sensitizing tumor cells to alkylating agents while leaving ...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-59678 | biostudies-arrayexpress
GenomicsTumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high grade glioma [bulkRNA-seq]
Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high grade glioma [bulkRNA-seq]
PRJNA968166 | ENA
GenomicsComprehensive molecular characterization of pediatric radiation-induced high-grade glioma
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma
PRJNA732694 | ENA
ProteomicsH2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in paediatric high-grade glioma cells
Diffuse intrinsic pontine gliomas (DIPG) are a deadly paediatric brain tumours, non-resectable due to brainstem localisation and diffusive growth. Patients with DIPG have a dismal prognosis of 9-12 months of survival with no effective therapy. Over 80% of DIPGs harbour a mutation in histone 3 (H3.3 ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-05 | MSV000093052 | MassIVE
GenomicsTumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high grade glioma [scRNA-seq]
Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high grade glioma [scRNA-seq]
PRJNA968165 | ENA
TranscriptomicsComparative genomic hybridization of high grade gliomas arising in children and young people
As genome-scale technologies begin to unravel the complexity of the equivalent tumours in adults, detailed characterisation of high grade gliomas in children have until recently been lacking. In order to validate and extend investigations of the differences between paediatric and adult tumours, we c...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-TABM-857 | biostudies-arrayexpress
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