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MetabolomicsGREM1 Deficiency induced Bone Marrow Adipose Niche promotes B-cell Acute Lymphoblastic Leukemia Disease Progression
Relapse and disease progression are the primary causes of treatment failure and subsequent mortality in children B-cell acute lymphocytic leukemia (B-ALL). At diagnosis and during treatment, the bone marrow adipose microenvironment is commonly observed in pediatric leukemia. However, the relationshi...
2024-09-23 | MTBLS10103 | MetaboLights
TranscriptomicsMicroRNAs characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia
MicroRNAs (miRNAs) regulate activity of protein-coding genes including those involved in hematopoietic cancers. The goal of the current study was to explore which miRNAs are unique for seven different subtypes of pediatric acute lymphoblastic leukemia (ALL). Therefore, the expression levels of 397 m...
ORGANISM(S): Homo sapiens 
2011-02-11 | E-GEOD-23024 | biostudies-arrayexpress
TranscriptomicsA Pre-clinical model of induction therapy and relapse in pediatric acute lymphoblastic leukemia
The development of a clinically relevant xenograft model of pediatric acute lymphoblastic leukemia, using a 4-drug treatment regimen designed to mimic pediatric remission induction therapy. Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clin...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MEXP-3916 | biostudies-arrayexpress
TranscriptomicsAffymetrix U133A array data for 111 pediatric acute myeloid leukemia (AML) samples at diagnosis
Genome-wide profiling of Copy Number Alterations (CNA) and Loss of Heterozygosity (LOH), gene expression and resequencing of pediatric AML This study characterizes CNA and LOH, gene expression and gene sequence mutations in a representative cross-section through subtypes of pediatric AML. Keywords...
ORGANISM(S): Homo sapiens 
2010-01-03 | E-GEOD-14471 | biostudies-arrayexpress
TranscriptomicsBone marrow gene expression of pediatric acute lymphoblastic leukemia (ALL)
Pediatric acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Subtype classification can be also achieved through gene expression profiling. However, how to apply such classifiers to a single patient and correctly diagnose the di...
ORGANISM(S): Homo sapiens 
2009-08-19 | E-GEOD-17703 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Sty2 SNP array
Genome-wide profiling of Copy Number Alterations (CNA) and Loss of Heterozygosity (LOH), gene expression and resequencing of pediatric AML. This study characterizes the CNA and LOH in a representative cross-section through subtypes of pediatric AML. Affymetrix SNP arrays were performed according to ...
ORGANISM(S): Homo sapiens 
2010-01-03 | E-GEOD-15731 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of basal gene expression in pediatric acute lymphoblastic leukemia xenograft cells
Analysis of basal gene expression in patient-derived xenograft cells. A panel of pediatric T-, B- and MLL-ALL xenografts was utilized to further understand the biology of leukemia Total RNA was isolated from patient-derived xenograft cells. Array analysis was carried out on Illumina beadchip HT12
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-52991 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Nsp SNP Array
Genome-wide profiling of Copy Number Alterations (CNA) and Loss of Heterozygosity (LOH), gene expression and resequencing of pediatric AML. This study characterizes the CNA and LOH in a representative cross-section through subtypes of pediatric AML. Affymetrix SNP arrays were performed according to ...
ORGANISM(S): Homo sapiens 
2010-04-13 | E-GEOD-15730 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Hind SNP array
Genome-wide profiling of Copy Number Alterations (CNA) and Loss of Heterozygosity (LOH), gene expression and resequencing of pediatric AML. This study characterizes the CNA and LOH in a representative cross-section through subtypes of pediatric AML. Affymetrix SNP arrays were performed according to ...
ORGANISM(S): Homo sapiens 
2010-01-03 | E-GEOD-15714 | biostudies-arrayexpress
TranscriptomicsTranscriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases
This SuperSeries is composed of the following subset Series: GSE35201: Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases [2007] GSE35202: Transcriptome ...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-35203 | biostudies-arrayexpress
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