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TranscriptomicsRNA-Seq of human neurons derived from iPS cells Reveals candidate long non-coding RNAs Involved in neurogenesis and neuropsychiatric disorders.
As a preliminary step towards applying next generation sequencing using neurons derived from patient-specific iPSCs, we have carried out an RNA-Seq analysis on control human neurons. Dramatic changes in the expression of coding genes, long non-coding RNAs (lncRNAs), pseudogenes, and splice isoforms ...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-32625 | biostudies-arrayexpress
TranscriptomicsTranscriptome of iPSC-derived Neural Cells with Heterozygous Knockout in CHD8
CHD8, encoding Chromodomain helicase DNA binding protein 8, is a top autism spectrum disorders (ASDs) risk gene. To better understanding the molecular links between CHD8 functions and ASD, we have applied the CRISPR/Cas9 technology to knockout one copy of CHD8 in induced pluripotent stem cells (iPSC...
ORGANISM(S): Homo sapiens 
2015-11-05 | E-GEOD-71594 | biostudies-arrayexpress
TranscriptomicsChIP-chip from fetal brain tissue with b-Catenin
GSK3b signaling has been implicated in the pathophysiology of bipolar affective disorder based on the inhibitory effect of lithium salts on this pathway. This has been supported by a recent genome wide association study. In addition, GSK3b signaling may also play a role in schizophrenia, an idea tha...
ORGANISM(S): Homo sapiens 
2010-04-01 | E-GEOD-21151 | biostudies-arrayexpress
TranscriptomicsDevelopment of patient-specific neurons in schizophrenia using induced pluripotent stem cells: proof of principle and preliminary findings
Induced pluripotent stem cell (iPSC) technology has the potential to address the inaccessibility of the human brain by providing investigators with patient-specific neurons that can potentially be used to carry out molecular, electrophysiological and pharmacological studies {{855 Takahashi,K. 2006}}...
ORGANISM(S): Homo sapiens 
2011-01-14 | E-GEOD-26629 | biostudies-arrayexpress
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