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ProteomicsSNORA33 Knockdown in chondrocytes
Background: In the experiment where we exposed chondrocytes of 4 healthy donors to OA-SF for 14 days we found several 2’O-methylation and pseudouridylation sites to be differentially modified in OA-SF condition compared to control (regular medium condition). We linked these PTMs to box C/D and H/ACA...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042545 | Pride
Human Snora33 Ribosome 
ProteomicsIMPAIRED CHONDROCYTE U3 SNORNA EXPRESSION IN OSTEOARTHRITIS AND ITS IMPACT ON THE CHONDROCYTE’S PROTEIN TRANSLATION APARATUS
Osteoarthritis (OA) is a chronic debilitating joint disease which is strongly associated with ageing. OA involves pathological cellular processes in all joint structures and affects articular cartilage integrity, leading to dysfunctional joint articulation. The biomolecular processes that catalyze t...
ORGANISM(S): Homo sapiens (Human) 
2020-08-21 | PXD017253 | Pride
Osteoarthritis Snorna Translation 
ProteomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. The underlying pathogenesis of OA is yet to be fully elucidated with no OA specific biomarkers in clinical u...
ORGANISM(S): Equus caballus (Horse) 
2020-08-03 | PXD017153 | Pride
Metabolomics Mass spectrometry Nuclear magnetic resonance Cartilage Proteomics Osteoarthritis 
ProteomicsThe Synovial Fluid Proteome Differentiates between Septic and Nonseptic Articular Pathologies
Presently few studies have investigated the proteomic profile of equine synovial fluid (SF) using high mass resolution mass spectrometer and in-solution trypsin digestion and to our knowledge none have investigated protein profile changes septic SF in any species. In this study we have used mass spe...
ORGANISM(S): Equus caballus (Horse) 
2019-05-01 | PXD011276 | Pride
Synovial fluid Proteomics Sepsis 
ProteomicsMetabolomic and Proteomic Stratification of Equine Osteoarthritis
Osteoarthritis (OA) is characterised by loss of articular cartilage, synovial membrane dysfunction and subchondral sclerosis. Few studies have used a global approach to stratify equine synovial fluid (SF) molecular profiles according to OA severity. SF was collected from 58 metacarpophalangeal (MCP)...
ORGANISM(S): Equus caballus (Horse) 
2025-02-17 | PXD019842 | Pride
Mass spectrometry Equine Synovial fluid Proteomics Osteoarthritis 
ProteomicsComparison of Rheumatoid Arthritis Patient and Control Sample Serum Proteomes
Rheumatoid arthritis is an autoimmune inflammatory joint condition which primarily affects the synovium of joints, characterised by synovial inflammation as well as articular cartilage and underlying bone destruction. Within this study, the proteomes of serum obtained from rheumatoid arthritis patie...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD020235 | Pride
Mass spectrometry Rheumatoid arthritis Serum Proteomics 
ProteomicsThe role of extracellular vesicles in synovial fibroblast senescence
In arthritis, synovial fibroblast (SF) senescence is linked to the activation of a pro-inflammatory phenotype contributing to chronic arthritis pathogenesis. Additionally, senescent cells accumulate in ageing tissues further promoting ageing and inflammation. These cells have dysregulated mitochondr...
ORGANISM(S): Homo sapiens (Human) 
2022-10-15 | PXD032757 | Pride
Human Extracellular vesicles Synovial fibroblasts Lc-ms/ms 
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