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KMP11 is an essential and highly conserved kinetoplastid protein. Using immunofluorescence, ultrastructure expansion microscopy and pulldown experiments, we show that KMP11 localizations in Trypanosoma brucei include the flagellum attachment zone, the paraflagellar rod, the flagellar connector, the ...
ORGANISM(S): Trypanosoma brucei 
2026-08-17 | PXD075274 | Pride
Mitochondrial protein import in the parasitic protozoan Trypanosoma brucei is mediated by the atypical outer membrane translocase, ATOM. It consists of seven subunits including ATOM69, the import receptor for hydrophobic proteins. Ablation of ATOM69, but not of any other subunit, triggers a unique q...
ORGANISM(S): Trypanosoma brucei 
2022-05-04 | PXD027739 | Pride
The mitochondrial proteome arises from dual genetic origin. Nuclear-encoded proteins need to be transported across or inserted into two distinguished membranes, and the TOM complex represents the main translocase in the outer mitochondrial membrane. Its composition and regulations have been extensiv...
ORGANISM(S): Homo sapiens (Human) 
2025-04-15 | PXD062441 | Pride
Protein import across the mitochondrial inner membrane typically depends on two protein translocases of the inner membrane (TIM) complexes and the membrane potential. The protozoan parasite Trypanosoma brucei, however, has a single, divergent TIM complex. Unlike other trypanosomal TIM subunits, TbTi...
ORGANISM(S): Trypanosoma brucei 
2025-10-27 | PXD061395 | Pride
The mitochondrial proteome arises from dual genetic origin. Nuclear-encoded proteins need to be transported across or inserted into two distinguished membranes, and the TOM complex represents the main translocase in the outer mitochondrial membrane. Its composition and regulations have been extensiv...
ORGANISM(S): Homo sapiens (Human) 
2025-04-15 | PXD062440 | Pride
The mitochondrial proteome arises from dual genetic origin. Nuclear-encoded proteins need to be transported across or inserted into two distinguished membranes, and the TOM complex represents the main translocase in the outer mitochondrial membrane. Its composition and regulations have been extensiv...
ORGANISM(S): Homo sapiens (Human) 
2025-04-15 | PXD062420 | Pride
The mitochondrial proteome arises from dual genetic origin. Nuclear-encoded proteins need to be transported across or inserted into two distinguished membranes, and the TOM complex represents the main translocase in the outer mitochondrial membrane. Its composition and regulations have been extensiv...
ORGANISM(S): Homo sapiens (Human) 
2025-04-15 | PXD062418 | Pride
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