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TranscriptomicsOncogene-like induction of cellular invasion from centrosome amplification
Centrosome amplification has long been recognized as a feature of human tumors, however its role in tumorigenesis remains unclear. Centrosome amplification is poorly tolerated by non-transformed cells, and, in the absence of selection, extra centrosomes are spontaneously lost. Thus, the high frequen...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-55042 | biostudies-arrayexpress
TranscriptomicsPolyploidy can drive rapid adaptation in yeast
Analysis of copy number variation in evolved haploid, diploid, tetraploid strains. All experimental samples were compared to the same reference strain S288C. The samples include the progenitor strains for the haploid, diploid, and tetraploid evolution experiments, and single colony isolates (clones...
ORGANISM(S): Saccharomyces cerevisiae 
2015-02-28 | E-GEOD-51017 | biostudies-arrayexpress
TranscriptomicsExpression data from the inducible expression of EWS-FLI1 (EF) in embryoid bodies
Oncogenic transformation in Ewing sarcoma tumors is driven by the fusion oncogene EWS-FLI1. The inducible expression of EWS-FLI1 (EF) in embryoid bodies, or collections of differentiating stem cells, generates cells with properties of Ewing sarcoma tumors, including characteristics of transformation...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-64686 | biostudies-arrayexpress
GenomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [ChIP-seq]
Children with Down syndrome (DS) have a 20-fold increased risk of developing B cell acute lymphoblastic leukemia (B-ALL). Polysomy 21 (i.e., extra copies of chr.21) is also the most frequent somatic aneuploidy among all B-ALLs. Additional B-ALLs harbor intrachromosomal amplifications of chr.21q22 (i...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48534 | biostudies-arrayexpress
TranscriptomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [RNA-Seq]
Down syndrome (DS) confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (ALL), yet the mechanisms underlying this association are undefined.  We show that triplication of only 31 genes orthologous to the putative DS Critical Region (DSCR) on chr.21q22 is sufficient to promote B ce...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48553 | biostudies-arrayexpress
UnknownHURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells
Not available
S-JCBD-201005065 | bioimages
UnknownHuman TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.
Not available
S-EPMC3164117 | biostudies-literature
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