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TranscriptomicsTranscription profiling by array of mesothelioma pre- and post-resistance biopsies in order to determine a resistance signature to pemetrexed/carboplatin treatment
Pemetrexed, a multi-folate inhibitor combined with a platinum compound is the first-line treatment of malignant mesothelioma, but median survival is still one year. Innate and acquired resistance to pemetrexed is common, but its biological basis is obscure. Here we report for the first time a genome...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-MTAB-1109 | biostudies-arrayexpress
TranscriptomicsPemetrexed alters inflammatory profile in EA.hy 926 cells grown under low-folate conditions.
Pemetrexed is an antifolate drug used in the treatment of lung cancer. EA.hy 926 cells grown under low (Lo) and normal (Hi) folate conditions were treated with PMX. Microarray analysis was used to examine changes in gene expression due to PMX treatment. Hi and Lo cells were grown to confluence and m...
ORGANISM(S): Homo sapiens 
2012-10-03 | E-GEOD-31986 | biostudies-arrayexpress
TranscriptomicsPemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma
We devised a high-throughput, cell-based assay to identify novel therapeutic compounds to treat Group3 medulloblastoma (G3 MB). Mouse G3 MBs, grown as neurospheres, were screened against a library of approximately 7,000 compounds including FDA-approved drugs. We identified two FDA-approved drugs, ...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-46406 | biostudies-arrayexpress
GenomicsUracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed
To test the effects of uracil DNA glycosylase (UNG) loss on the formation of double strand breaks (DSBs) by the anti-cancer agent pemetrexed, we performed ChIP-seq for serine 139-phosphorylated H2AX (gammaH2AX), a marker of DSBs, in human cells wild-type or deficient for UNG in combination with peme...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-50692 | biostudies-arrayexpress
TranscriptomicsChemotherapy plus EGFR-TKI as first-line treatment provides better survival for advanced EGFR positive lung adenocarcinoma patients: updated data and exploratory in vitro study
To probe into the potential mechanisms contributing to the strong synergistic interaction between gefitinib and pemetrexed, gene expression profiles of PC-9 cells exposed to gefitinib, pemetrexed or combined treatment were analyzed using microarray technique.
ORGANISM(S): Homo sapiens 
2020-03-12 | E-MTAB-8661 | biostudies-arrayexpress
ProteomicsCytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA
The cytotoxic mechanisms of thymidylate synthase inhibitors, such as the multitarget antifolate pemetrexed, are not yet fully understood. Emerging evidence indicates that combining pemetrexed with histone deacetylase inhibitors (HDACi) may enhance therapeutic efficacy in non-small cell lung cancer (...
ORGANISM(S): Homo sapiens (Human) 
2024-12-18 | PXD051824 | Pride
Ber Double strand breaks Base excision repair Histone deacetylase Ap Dihydrofolate reductase Dutpase dut Dhfr Apyrimidinic Deoxyuridine triphosphate nucleotide hydrolase Gart Trifunctional purine biosynthetic protein adenosine 3 Hdac Hdaci Dsb 
GenomicsThe antifolate pemetrexed induces innate tolerance in human macrophages
The antifolate pemetrexed induces innate tolerance in human macrophages
PRJNA668719 | ENA
ProteomicsWarburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis
Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis
ORGANISM(S): Homo Sapiens 
2023-07-10 | PXD043632 |
ProteomicsDiscovery proteomics studies for the identification of a protein panel associated with the response to pemetrexed in platinum drug resistant cancer
Pemetrexed is a drug largely used in lung cancer, mesothelioma and proposed in some cases of ovarian cancers, a particularly severe cancer type. In this latest tumor type, therapy relies on debulking surgery and platinum-based chemotherapy. Despite the initial high response rates to platinum drugs, ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD007056 | Pride
Platinum drug resistance Lc ms/ms Ovarian cancer Discovery proteomics 
ProteomicsIdentification of proteins related with pemetrexed resistance by iTRAQ and PRM-based comparative proteomic analysis in non-small cell lung cancer cells
Identification and validation of proteins related with pemetrexed resistance
ORGANISM(S): Homo Sapiens 
2020-09-24 | PXD021674 |
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