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TranscriptomicsTracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells (embryo single cell RNA-sequencing)
Rabbit embryos, as in humans, develop as bilaminar discs at gastrulation and unlike egg cylinders as in rodents. Mammalian primordial germ cells (PGCs) in all species originate during gastrulation. We sequence the transcriptomes of rabbit embryos during gastrulation, and show that rabbit PGC (rbPGC...
ORGANISM(S): Oryctolagus cuniculus 
2021-10-14 | E-MTAB-10894 | biostudies-arrayexpress
TranscriptomicsDNA methylation in marmoset primed and naive pluripotent stem cells, and trophoblast stem cells
Bisulfite sequencing on bulk populations of marmoset naïve pluripotent stem cells (PSC), primed PSC, and trophoblsat stem cells.
ORGANISM(S): Callithrix jacchus 
2024-11-21 | E-MTAB-12453 | biostudies-arrayexpress
TranscriptomicsHuman and marmoset trophoblast stem cells differ in signalling requirements and recapitulate divergent modes of trophoblast invasion
We derive experimental conditions for the derivation of marmoset trophoblast like cells. Marmoset naïve PSC form extraembryonic mesoderm in human TSC conditions, whilst TGFβ/NODAL, FGF/ERK and WNT signalling control marmoset peri- and postimplantation trophoblast identity.
ORGANISM(S): Callithrix jacchus 
2024-11-21 | E-MTAB-12463 | biostudies-arrayexpress
TranscriptomicsTracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells (cell culture)
Rabbit embryos, as in humans, develop as bilaminar discs at gastrulation and unlike egg cylinders as in rodents. Mammalian primordial germ cells (PGCs) in all species originate during gastrulation. We sequence the transcriptomes of rabbit embryos during gastrulation, and show that rabbit PGC (rbPGC...
ORGANISM(S): Oryctolagus cuniculus 
2021-10-14 | E-MTAB-10893 | biostudies-arrayexpress
TranscriptomicsPrimed and naïve marmoset pluripotent stem cells as a model for primate development
We derived primed pluripotent stem cell cultures (PSCs) from marmoset blastocyst using conventional human PSC culture conditions (KSR/bFGF on feeders). Naïve marmoset PSCs were established by chemical resetting. In addition, we generated forebrain-derived cells from the frontal lobe of a marmoset ne...
ORGANISM(S): Callithrix jacchus 
2022-02-14 | E-MTAB-9349 | biostudies-arrayexpress
TranscriptomicsTracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells (bulk RNA-sequencing)
Rabbit embryos, as in humans, develop as bilaminar discs at gastrulation and unlike egg cylinders as in rodents. Mammalian primordial germ cells (PGCs) in all species originate during gastrulation. We sequence the transcriptomes of rabbit embryos during gastrulation, and show that rabbit PGC (rbPGC...
ORGANISM(S): Oryctolagus cuniculus 
2021-10-14 | E-MTAB-10892 | biostudies-arrayexpress
TranscriptomicsEmbryo methylation profiling in marmosets
Here we perform Bisulfite sequencing (BS-seq) on marmoset post-implantation embryos following laser capture micro dissection to capture methylation profiles of post-implantation tissues. We also perform single-cell BS-seq on pre-implantation marmoset embryos from four-cell to the compacted morula st...
ORGANISM(S): Callithrix jacchus 
2024-09-22 | E-MTAB-13893 | biostudies-arrayexpress
TranscriptomicsA Local Regulatory Network Around Three NAC Transcription Factors in Stress Responses and Senescence in Arabidopsis leaves (expression between lines at timepoints).
A network model has been generated that describes the immediate gene expression cascade surrounding three similar but distinct NAC transcription factors that have roles to play in leaf senescence and in many stress responses in Arabidopsis. ANAC019, ANAC055 and ANAC072 belong to the same clade of N...
ORGANISM(S): Arabidopsis thaliana 
2013-04-23 | E-GEOD-45183 | biostudies-arrayexpress
TranscriptomicsA Local Regulatory Network Around Three NAC Transcription Factors in Stress Responses and Senescence in Arabidopsis leaves (Botrytis cinerea infection).
A network model has been generated that describes the immediate gene expression cascade surrounding three similar but distinct NAC transcription factors that have roles to play in leaf senescence and in many stress responses in Arabidopsis. ANAC019, ANAC055 and ANAC072 belong to the same clade of N...
ORGANISM(S): Arabidopsis thaliana 
2013-04-23 | E-GEOD-45594 | biostudies-arrayexpress
TranscriptomicsPrimordial germ cell like cell competent populations
We sequenced human embryonic stem cells (hESCs), pre-mesendoderm cells (PreME) that acquire transient competence for PGCLC specification and cells at the mesendoderm (ME) stage when they are not longer PGC-competent.
ORGANISM(S): Homo sapiens 
2022-01-21 | E-MTAB-11135 | biostudies-arrayexpress
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