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ProteomicsProteome profiling of mouse germinal center B cells
Productive B cell responses are critical to protect a host from infection. The spleen and lymph nodes are populated by resting follicular B cells, which can enter germinal centers upon antigen encounter. Once in the germinal center, B cells migrate between the dark and light zones, where they underg...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-06 | PXD015524 | Pride
Mouse B cells 
MetabolomicsMetabolomics of human primary B-ALL cells treated by BCR-Abl1 inhibitor, STI571, and p190 BCR-Abl+ BAF3 cells with ASS1 knockdown
Analyze the Metabolomics changes in B-ALL cells after the treatment of imatinib and p190+ BAF3 cells with ASS1 knockdown or left untreated. two methods as the below LC-MS description showed were used.
2026-07-08 | MTBLS14638 | MetaboLights
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
TranscriptomicsTranscription profiling of mouse B cells expressing anti-HEL IgM BCR and IgMG BCR to investigate the effect of IgG cytoplasmic tail on BCR-respose genes
IgG cytoplasmic tail interferes with the induction of antigen-response genes Experiment Overall Design: Comparing antigen-induced genes between B cells expressing anti-HEL IgM BCR and IgMG BCR (chimeric receptor where the extracellular spacer, transmembrane, and cytoplasmic domain of IgM are replace...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7218 | biostudies-arrayexpress
ProteomicsCovalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted
Many archetypal and emerging classes of small-molecule therapeutics form covalent 38 protein adducts. In vivo, both the resulting conjugates and their off-target side conjugates have the potential to elicit antibodies, with implications for allergy and drug sequestration. Although β-lactam antibioti...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2024-08-08 | PXD052026 | Pride
B-lactam Proteomics 
ProteomicsSchisandrin B exhibits anti-proliferative effects by inducing ferroptosis in pancreatic cancer
Sch B exerts anti-proliferative effects at least partially by inducing ACSL4-dependent ferroptosis in PC
ORGANISM(S): Homo Sapiens 
2026-05-06 | PXD078099 |
TranscriptomicsTranscription profiling of human circulating B Lymphocytes from patients with high or low bone density
B cells produce important cytokines regulate bone metabolism. We comparison gene expression patterns of circulating B cells in blood from 20 postmenopausal females with low or high bone mineral density (BMD): 10 low BMD vs. 10 high BMD. In total 29 differentially expressed genes were identified incl...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-7429 | biostudies-arrayexpress
MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
TranscriptomicsTranscription profiling of human B-lymphocytes from postmenopausal female smokers with high or low bone mineral density
B cells produce important cytokines regulate bone metabolism. We comparison gene expression patterns of circulating B cells in blood from 20 postmenopausal female smokers with low or high bone mineral density (BMD): 10 low BMD vs. 10 high BMD. In total 17 differentially expressed genes were identifi...
ORGANISM(S): Homo sapiens 
2009-10-20 | E-GEOD-13850 | biostudies-arrayexpress
GenomicsEpstein-Barr Virus Exploits Intrinsic B-Lymphocyte Transcription Programs to Achieve Immortal Cell Growth
Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) gene regulation through the cell RBPJ transcription factor (TF) is essential for conversion of resting B-lymphocytes (RBLs) into Lymphoblastoid Cell Lines (LCLs). ChIP-seq investigation of EBNA2 and RBPJ sites in LCL DNA found EBNA2 at 5151 and RBPJ at 10...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-29498 | biostudies-arrayexpress
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