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GenomicsCoordinated regulation of osmotic imbalance by c-di-AMP shapes ß-lactam tolerance in Group B Streptococcus
Coordinated regulation of osmotic imbalance by c-di-AMP shapes ß-lactam tolerance in Group B Streptococcus
PRJNA1090533 | ENA
ProteomicsCovalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted
Many archetypal and emerging classes of small-molecule therapeutics form covalent 38 protein adducts. In vivo, both the resulting conjugates and their off-target side conjugates have the potential to elicit antibodies, with implications for allergy and drug sequestration. Although β-lactam antibioti...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2024-08-08 | PXD052026 | Pride
B-lactam Proteomics 
Genomics
Selective Evolution of Methanogenic Communities by B Lactam Antibiotics Promotes Methane Production
PRJNA1223818 | ENA
ProteomicsBiotin-Labelled Clavulanic Acid to Identify Proteins Target for Haptenation in Serum: Implications in Allergy Studies
Clavulanic acid (CLV) and amoxicillin, frequently administered in combination, can be independently involved in allergic reactions. Protein haptenation with β-lactams is considered necessary to activate the immune system. The aim of this study was to assess the suitability of biotinylated analogues ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021727 | Pride
Betalactam Drug allergy Clavulanate Biotinylation Biotin tag Haptenation 
UnknownOptical microscopy reveals the dynamic nature of B. pseudomallei morphology during β-lactam antimicrobial susceptibility testing.
Not available
S-EPMC7364477 | biostudies-literature
GenomicsAcid-dependent beta-lactam resistance in Klebsiella pneumoniae is mediated by paralogous class B PBPs and the class A PBP, PBP1b
Acid-dependent beta-lactam resistance in Klebsiella pneumoniae is mediated by paralogous class B PBPs and the class A PBP, PBP1b
PRJNA1234613 | ENA
UnknownIsolation of group B Streptococcus with reduced β-lactam susceptibility from pregnant women.
Not available
S-EPMC6455180 | biostudies-literature
TranscriptomicsAcid-dependent beta-lactam resistance in Klebsiella pneumoniae is mediated by paralogous class B PBPs and the class A PBP, PBP1b
Klebsiella pneumoniae is a leading cause of global deaths due to antibiotic resistance. Of particular concern, is the rapid expansion within K. pneumoniae lineages of resistance to beta-lactams, the most prescribed class of antibiotics. Additionally, the environmental factors that influence pathogen...
ORGANISM(S): Klebsiella pneumoniae Escherichia coli str. K-12 substr. MG1655 
2025-03-17 | GSE291667 | GEO
UnknownPoint mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics.
Not available
S-EPMC2493126 | biostudies-literature
UnknownDiscovery and Optimization of Seven-Membered Lactam-Based Compounds to Phenocopy the Inhibition of the Aurora Kinase B.
Not available
S-EPMC9290026 | biostudies-literature
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