Sort   by:  
 Page size 
ProteomicsBiotin-Labelled Clavulanic Acid to Identify Proteins Target for Haptenation in Serum
Clavulanic acid (CLV) is a betalactam (BL) which inhibits betalactamases activity and is frequently administered combined with amoxicillin (AX). Both BLs can be independently involved in allergic reactions. Indeed, selective immediate allergic reactions to CLV have recently been reported in 30% of p...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021675 | Pride
Clavulanate Blot and biotin detection Clavulanic acid Biotinylation Biotin tag Haptenation 
ProteomicsBiotin-Labelled Clavulanic Acid to Identify Proteins Target for Haptenation in Serum: Implications in Allergy Studies
Clavulanic acid (CLV) and amoxicillin, frequently administered in combination, can be independently involved in allergic reactions. Protein haptenation with β-lactams is considered necessary to activate the immune system. The aim of this study was to assess the suitability of biotinylated analogues ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021727 | Pride
Betalactam Drug allergy Clavulanate Biotinylation Biotin tag Haptenation 
ProteomicsAMOXICILLIN HAPTENATION OF α-ENOLASE
Allergic reactions to antibiotics are a major concern in the clinic, with almost 15% of the patients presenting with adverse reactions against β-lactam antibiotics. One of the mechanisms involved in this outcome is the modification of proteins by covalent binding of the drug (haptenation). Hence, th...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029712 | Pride
Β-lactam antibiotics  protein modification by drugs  mass spectrometry  posttranslational modifications  acetylation  allergic responses to drugs 
UnknownAmoxicillin Haptenation of α-Enolase is Modulated by Active Site Occupancy and Acetylation.
Not available
S-EPMC8793629 | biostudies-literature
UnknownBiotin-Labelled Clavulanic Acid to Identify Proteins Target for Haptenation in Serum: Implications in Allergy Studies.
Not available
S-EPMC7797785 | biostudies-literature
UnknownDetermination of Protein Haptenation by Chemical Sensitizers Within the Complexity of the Human Skin Proteome.
Not available
S-EPMC5889026 | biostudies-literature
ProteomicsHaptenation of Macrophage Migration Inhibitory Factor
Firstly, the adductome of the two major mouse blood proteins, as well as of the protein macrophage migration inhibitory factor (MIF) with the model hapten tetramethylrhodamine isothiocyanate (TRITC)was invastigated. After incubation at different molar ratios of TRITC, an untargeted Full MS/dd-MS2 ex...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-08 | PXD031143 | Pride
High resolution mass spectrometry (hrms) Macrophage migration inhibitory factor (mif) Contact allergy Tetramethylrhodamine isothiocyanate (tritc) Allergic contact dermatitis (acd) Biomarkers 
ProteomicsHaptenation of Macrophage Migration Inhibitory Factor-Dataset 2
Firstly, the adductome of he protein macrophage migration inhibitory factor (MIF) with different haptens encompassing different reaction mechanisms and potencies was investigated. After incubation of MIF with the different haptens at 5 times molar excess of hapten, an untargeted Full MS/dd-MS2 exper...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-18 | PXD031793 | Pride
Pge Dncb Cmit/mit Mif Biomarker Ca 
UnknownHaptenation of Macrophage Migration Inhibitory Factor: A Potential Biomarker for Contact Hypersensitivity.
Not available
S-EPMC9019732 | biostudies-literature
UnknownCharacterization of the Class I MHC Peptidome Resulting From DNCB Exposure of HaCaT Cells.
Not available
S-EPMC7916740 | biostudies-literature
Sort   by:  
 Page size