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The aim of this experiment was to investigate the role of MIF during wound healing using BALB/C MIF null mice and in the context of reduced estrogen-associated impaired healing using ovariectomized mice (a mouse model of age-associated delayed healing). Ageing is associated with delayed cutaneous wo...
ORGANISM(S): Mus musculus 
MIF deficiency reduces chronic inflammation in white adipose tissue and impairs development of insulin resistance, glucose intolerance and associated atherosclerotic disease
ORGANISM(S): Mus musculus 
siRNA-mediated knockdown of MIF expression in HEK293 cells resulted in inhibition of cell proliferation and cell cycle progress. The microarray study of MIF KD cells reveald knockdown of MIF would lead to extensive changes in gene expression profiles which may elucidate the molecular mechanism of...
ORGANISM(S): Homo sapiens 
The presence of activated pancreatic stellate cells (PSCs) in the pancreatic ductal adenocarcinoma (PDAC) microenvironment plays a significant role in cancer progression. Macrophage migration inhibitory factor (MIF) is overexpressed in PDAC tissues and expressed by both cancer and stromal cells. The...
ORGANISM(S): Mus musculus 
NIH 3T3 fibroblasts that express little detectable levels of the MIF binding receptor CD74 but do express the signalling component CD44 were used for the identification of interacting proteins that are shared by MIF and D-DT. Endogenously expressed MIF and D-DT were tagged at the C-terminus using a ...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-27 | PXD020449 | Pride
Firstly, the adductome of the two major mouse blood proteins, as well as of the protein macrophage migration inhibitory factor (MIF) with the model hapten tetramethylrhodamine isothiocyanate (TRITC)was invastigated. After incubation at different molar ratios of TRITC, an untargeted Full MS/dd-MS2 ex...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-08 | PXD031143 | Pride
Firstly, the adductome of he protein macrophage migration inhibitory factor (MIF) with different haptens encompassing different reaction mechanisms and potencies was investigated. After incubation of MIF with the different haptens at 5 times molar excess of hapten, an untargeted Full MS/dd-MS2 exper...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-18 | PXD031793 | Pride
Transcriptome profiling of neutrophils in curdlan-injected Wild Type SKG mice and Mif KO (Mif -/-) SKG mice
MIF Nuclease Inhibition Protects CNS Neurons following Inflammation
Pathways linking aging and atheroprotection in Mif-deficient atherosclerotic mice
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