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TranscriptomicsExpression profiles of primary bone marrow derived mouse macrophages M-bM-^@M-^S untreated and treated with LPS or LPS+PGE
The polarization of macrophages into an anti-inflammatory or regulatory phenotype plays an important role in resolving inflammation. PGE2 regulates macrophage polarization via a PKA dependent pathway. PKA phosphorylates SIKs, inhibiting their ability to phosphorylate CRTC3 in cells. This in turn ...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-41833 | biostudies-arrayexpress
TranscriptomicsDifferential features of Aire-induced and Aire-independent promiscuous gene expression in thymic epithelial cells
Promiscuous gene expression (pGE) of numerous self-antigens in thymic epithelial cells (TEC) enables the elimination of self-reactive T cells. The autoimmune regulator (Aire) is the only known molecular determinant driving pGE in the thymus but the existence of Aire-independent mechanisms has been i...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-65617 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung to study the effect of prostaglandin E receptor subtype EP3 on mouse asthma model.
We examined the effect of PGE receptor EP3 subtype on mouse OVA-induced asthma model. We treat EP3 agonist 3h after OVA challenge. After 24 h of 3rd OVA challenge, whole lung was isolated and the gene expression change was determined.
ORGANISM(S): Mus musculus 
2007-09-25 | E-GEOD-2276 | biostudies-arrayexpress
TranscriptomicsEffect of PGE receptor EP3 subtype agonist on mouse asthma model
We examined the effect of PGE receptor EP3 subtype on mouse OVA-induced asthma model. We treat EP3 agonist 3h after OVA challenge. After 24 h of 3rd OVA challenge, whole lung was isolated and the gene expression change was determined. Keywords: other
ORGANISM(S): Mus musculus 
2005-02-18 | GSE2276 | GEO
ProteomicsBidirectional interaction between PGE₂-preconditioned mesenchymal stem cells and myofibroblasts mediates antifibrotic effects: A proteomic investigation into equine endometrial fibrosis reversal
Endometrosis is a prevalent fibrotic condition in mares that impairs reproductive efficiency by inducing transdifferentiation of endometrial stromal cells into myofibroblasts, leading to excessive ECM deposition. Methods: To elucidate the molecular mechanisms underlying fibrosis resolution, this stu...
ORGANISM(S): Equus caballus (Horse) 
2025-09-29 | PXD067551 | Pride
Endometrosis  equine mesenshymal stem cells  mare endometrial  precondition with pge2  silac  myofibloblasts - equine mesenshymal stem cells interaction 
UnknownUrinary PGE-M in Men with Prostate Cancer.
Not available
S-EPMC8391815 | biostudies-literature
UnknownUrinary PGE-M Levels and Risk of Ovarian Cancer.
Not available
S-EPMC6825569 | biostudies-literature
TranscriptomicsExpression data from cumulus cells from C57Bl/6 and Ptger2 (EP2) KO mice
To understand the role of prostaglandin (PG) receptor EP2 (Ptger2) signaling in ovulation and fertilization, we investigated time-dependent expression profiles in wild-type (WT) and Ptger2-/- cumuli before and after ovulation by using microarrays. We used Affymetrix U74A ver2 microarrays to investig...
ORGANISM(S): Mus musculus 
2010-03-02 | E-GEOD-20439 | biostudies-arrayexpress
GenomicsASE in mealybugs under PGE
Males that silence their father’s genes: genomic imprinting of a complete haploid genome
PRJEB39446 | ENA
UnknownSelective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity.
Not available
S-EPMC3151318 | biostudies-literature
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