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ProteomicsTemplate-based assembly of proteomic short reads for de novo antibody sequencing and repertoire profiling
We developed a software package STITCH (https://github.com/snijderlab/stitch) to perform template-based assembly of de novo peptide reads from antibody samples. As a test case we generated de novo peptide reads from protein G purified whole IgG from COVID-19 patients.
ORGANISM(S): Homo sapiens (Human) 
2022-07-21 | PXD031941 | Pride
De novo  antibody  serum 
UnknownIntroducing π-HelixNovo for practical large-scale de novo peptide sequencing.
Not available
S-EPMC10858680 | biostudies-literature
UnknownPericapsular Nerve Group (PENG) block versus fascia iliaca compartment (FI) block for hip surgery: a systematic review and meta-analysis of randomized controlled trials.
Not available
S-EPMC10625158 | biostudies-literature
ProteomicsAcute proteome responses to de novo sphingolipid synthesis inhibition suggest cancer combination therapies
Sphingolipids are essential structural and signaling lipids that support membrane integrity and govern cell fate decisions. Whereas the consequences of chronic sphingolipid inhibition have been extensively explored, the immediate cellular responses to reduced sphingolipid levels remain poorly define...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD079016 | Pride
Cancer Myriocin Proteome De novo sphingolipid synthesis 
UnknownEffectiveness of pericapsular nerve group block for hip fracture pain management in the emergency department: results of the ED-PENG-B randomised controlled trial.
Not available
S-EPMC12659107 | biostudies-literature
UnknownThe utility of pericapsular nerve group (PENG) block versus intrathecal morphine for postoperative analgesia in anterior approach total hip arthroplasty: a multicentre triple blinded randomised controlled trial protocol.
Not available
S-EPMC12482444 | biostudies-literature
ProteomicsDe Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma
Pleural mesothelioma (PM) is one of the deadliest cancers, with limited therapeutic options due to its therapeutically intractable genome, which is characterized by the functional inactivation of tumor suppressor genes (TSGs) and high tumor heterogeneity, including diverse metabolic adaptations. How...
ORGANISM(S): Homo sapiens (Human) 
2025-07-08 | PXD063342 | Pride
Metabolic diversity De novo pyrimidine synthesis Neurofibromin 2 (nf2) Pleural mesothelioma (pm) Synthetic lethality 
UnknownBuffering updates enables efficient dynamic de Bruijn graphs.
Not available
S-EPMC8326735 | biostudies-literature
UnknownA New General Correlation for the Influence Parameter in Density Gradient Theory and Peng-Robinson Equation of State for <i>n</i>-Alkanes.
Not available
S-EPMC11643655 | biostudies-literature
ProteomicsMS-based sequencing of the anti-FLAG-M2 antibody
We demonstrate a method for direct de novo sequencing of monoclonal IgG from the purified antibody products. The method uses a panel of multiple complementary proteases to generate suitable peptides for de novo sequencing by LC-MS/MS in a bottom-up fashion. Furthermore, we apply a dual fragmentation...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-01-11 | PXD023419 | Pride
Antibody Stepped hcd Ethcd De novo sequencing 
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