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TranscriptomicsProbucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice
To discern whether the same transcriptional signature of mitochondrial dysfunction previously reported in B6.Alb/cre,Pdss2loxP/loxP liver-conditional knockout mice (Peng, Falk et al. PLoS Genetics, 2008 [PMID 18437205]) was present regardless of Pdss2 mutation type, as well as to assess whether phar...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-27954 | biostudies-arrayexpress
ProteomicsChanges of exosomes expression after long term exposure to 2.856 and 9.375 GHz microwaves
Changes of exosomes expression after long term exposure to 2.856 and 9.375 GHz microwaves.
ORGANISM(S): Rattus Rattus 
2022-09-01 | PXD036462 |
ProteomicsChanges of protein expression after long term exposure to 2.856 GHz and 9.375 GHz microwaves
Changes of protein expression in hippocampus after long term exposure to 2.856 GHz and 9.375 GHz microwaves
ORGANISM(S): Rattus Norvegicus 
2022-08-19 | PXD036155 |
ProteomicsIdentification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain
In order to combat molecular damage, most cellular proteins undergo rapid turnover. We have previously identified large nuclear protein assemblies that can persist for years in post-mitotic tissues and are subject to age-related decline. Here we report that mitochondria can be long-lived in the mous...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-04 | PXD028963 | Pride
Mitochondria  protein homeostasis  long-lived proteins  electron transport chain 
TranscriptomicsA long noncoding RNA protects the heart from pathological hypertrophy
The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo antisense transcription1, including myosin heavy chain 7 (Myh7), which encodes molecular motor proteins for heart contraction2. Her...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-49716 | biostudies-arrayexpress
TranscriptomicsLong noncoding RNAs are spatially correlated with transcription factors and regulate lung development
To identify potential biological functions for three lncRNAs (NANCI, LL12, and LL34) we used shRNAs to knockdown expression of lncRNAs in MLE12 cells, a cell resembling type two lung epithelial cells. This data set contains the microarrays looking at gene expression. We used biological triplicate fo...
ORGANISM(S): Mus musculus 
2014-07-22 | E-GEOD-52389 | biostudies-arrayexpress
UnknownDiscovery, identification, and functional characterization of long noncoding RNAs in Arachis hypogaea L.
Not available
S-EPMC7330965 | biostudies-literature
TranscriptomicsCapicua-dependent transcriptional changes in adult mouse cerebellum
Analysis of cerebella from Capicua (Cic) mutant mice and wild-type controls at 28 days of age (P28). Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). The transcriptional repressor Cic binds directly to Atxn1...
ORGANISM(S): Mus musculus 
2011-11-07 | E-GEOD-32051 | biostudies-arrayexpress
TranscriptomicsGenome-wide sequencing small RNAs in response to powdery mildew and heat stress in wheat
To test whether non-coding RNAs play roles in regulating response to powdery mildew infection and heat stress in wheat, by using Solexa high-throughput sequencing and computational analysis and experimental approach we cloned the small RNAs and identified 125 putative long npcRNAs from wheat leaves ...
ORGANISM(S): Triticum aestivum 
2011-02-15 | E-GEOD-27327 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling analysis in Populus yunnanensis provides insights into the molecular mechanisms of sexual differences in plant salinity tolerance
In the present study, we compared transcriptional response to salinity between male and female individuals of Populus yunnanensis. We found that several functional groups of genes involved in important pathways were differentially expressed, including photosynthesis-related genes which were mainly u...
ORGANISM(S): Populus yunnanensis 
2012-01-20 | E-GEOD-35223 | biostudies-arrayexpress
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