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TranscriptomicsGenome-wide analysis of CD8 cells laser captured from skin biopsies during the mucocutaneous HSV-2 reactivation
Analysis of CD8 cells at the gene expression level during the genital HSV-2 reactivation. We would like to get a comprehensive overview on gene expression of CD8 T-cells during the post healing phases of HSV-2 reactivation. The hypothesis is that CD8 T-cells play a immune surveillance function durin...
ORGANISM(S): Homo sapiens 
2012-07-25 | E-GEOD-39625 | biostudies-arrayexpress
ProteomicsSEPT6 affinity purification-mass spectrometry (AP-MS)
Septin proteins interact intermolecularly to form hetero-oligomeric complexes that further assemble into higher-order filaments. To investigate whether the interactions among septin proteins are affected by RID, we conducted affinity purification-mass spectrometry (AP-MS) experiments. In this regard...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD046497 | Pride
Sept6 Rid Fatty-acylation 
ProteomicsA Bioorthogonal Chemical Reporter for the Detection and Identification of Protein Lactylation
L-Lactylation is a recently discovered post-translational modification occurring on histone lysine residues to regulate gene expression. However, the substrate scope of lactylation, especially that in non-histone proteins, remains unknown, largely due to the limitations of current methods for analyz...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD033454 | Pride
Chemical reporter Chemical proteomics Lactylation 
ProteomicsQuantitative chemical proteomics profile target proteins of ITCs
Quantitative chemical proteomics was performed to profile the target proteins of ITCs.For the forward SILAC experiment, heavy-labeled cells were treated with the ITC probe (20 μM) for 30 min and light-labeled cells were pre-treated with the natural ITC (60 μM) for 30 min, followed by the ITC probe (...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051941 | Pride
Human Silac Chemical proteomics Isothiocyanates Hf-x 
ProteomicsChemical proteomics of RID substrates
To globally profile the fatty-acylation substrate proteins of RID, we utilized the bioorthogonal chemical reporter Alk-16, an alkynyl-functionalized fatty acid analogue, to metabolically label fatty-acylated proteins in living cells. To identify the substrate proteins of RID, we sought to perform qu...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD046500 | Pride
Rid Chemical proteomics 
ProteomicsProteomics insights into the molecular mechanisms of c9, t11-CLA synthesis
Cis-9, trans-11-conjugated linoleic acid (c9, t11-CLA), a functional fatty acid, is one of the research hotspots in the fields of functional dairy products development because of its multiple beneficial effects in humans and animals. In milk, most c9, t11-CLA is de novo synthesized from trans-11-oct...
ORGANISM(S): Bos taurus (Bovine) 
2022-08-12 | PXD028620 | Pride
Cis-9 Trans-11-conjugated linoleic acid  stearoyl-coa desaturase 1  mac-t cells  proteomics  functional fatty acid 
ProteomicsViral control by a unique cytotoxic SARS-CoV-2 spike protein-specific CD4+ T cell population
Little is known of the role of cytotoxic CD4+ T-cells (CTLs) in the control of human viral replication. Here, we investigate CD4+ T-cell responses to three immunodominant SARS-CoV-2 epitopes identified in our study cohort, and evaluate cytotoxic activity and antiviral cytokine production in response...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2025-08-15 | PXD042469 | Pride
Human Epitotpes Sars-cov-2 Cd4+ tcells Lc-ms/ns 
UnknownQuantifying Personalized Shift-Work Molecular Portraits Underlying Alzheimer's Disease through Computational Biology.
Not available
S-EPMC11573866 | biostudies-literature
ModelsZou2007_MAPK_SignalingNetworks
This a model from the article: Modeling specificity in the yeast MAPK signaling networks Zou X, Peng T, Pan Z J. Theor. Biol. (2008);250(1):139-55 17977559 , Abstract: Cells sense several kinds of stimu...
2005-01-01 | MODEL7519354389 | BioModels
TranscriptomicsTranscriptional profiling of CD8 cells laser captured from skin biopsies at dermal-epidermal junction and at deeper dermal area near blood vessel during the healed phase of mucocutaneous HSV-2 reactivation
We aim to get a comprehensive analysis on gene expression of CD8a+ T-cells during the post healed phases of HSV-2 reactivation at different anatomic location (CD8a+ cells at dermal-epidermal junction versus CD8a+ cells in deeper dermal area near blood vessel). Our hypothesis is that JC_CD8 cells may...
ORGANISM(S): Homo sapiens 
2013-04-11 | E-GEOD-44975 | biostudies-arrayexpress
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