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ProteomicsMULTI-TARGETED FLAVONOID INHIBITION OF THE PATHOGENIC BACTERIUM STAPHYLOCOCCUS AUREUS: A Proteomic Characterization
Growth inhibition of the pathogen Staphylococcus aureus with currently available antibiotics is problematic in part due to bacterial biofilm protection. While Although the recently characterized natural products, including 3´,4´,5-trihydroxy-6,7-dimethoxy-flavone [1], 3´,4´,5,6,7-pentahydroxy-flavon...
ORGANISM(S): Staphylococcus aureus 
2017-05-30 | PXD006030 | Pride
Antibacterial flavonoids  lc-ms/ms proteomics  multi-targeted bacterial inhibition Staphylococcus aureus 
ProteomicsEnhanced Quantitative LC-MS/MS Analysis of N-linked Glycans Derived from Glycoproteins Using Sodium Deoxycholate Detergent
Protein glycosylation is a common protein post-translational modification (PTM) in living organisms and has been shown to associate with multiple diseases, and thus may potentially be a biomarker of such diseases. Efficient protein/glycoprotein extraction is a key step in the preparation of N-glycan...
ORGANISM(S): Homo sapiens (Human) 
2018-05-16 | PXD008687 | Pride
Acidic labile detergent Detergent removal Lc-ms/ms sample preparation N-glycomics Sodium deoxycholate 
UnknownDiscovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors.
Not available
S-EPMC6580535 | biostudies-literature
ProteomicsComparative Membrane Proteomics Analyses of Breast Cancer Cell Lines to Understand the Molecular Mechanism of Breast Cancer Brain Metastasis
Breast cancer is the leading type of cancer in women. Breast cancer brain metastasis is considered as an essential issue in breast cancer patients. Membrane proteins play important roles in breast cancer brain metastasis that contributes to the cell adhesion and penetration of blood-brain barrier. T...
ORGANISM(S): Homo sapiens (Human) 
2017-05-23 | PXD005719 | Pride
Proteomics Breast cancer brain metastasis Membrane enrichment Differential expression analysis Lc-ms/ms 
ProteomicsIntegrated Transcriptomics, Proteomics and Glycomics for a Deeper Insight of the Mechanism of Breast Cancer Brain Metastasis: Emphasizing on Glycosylation
Breast cancer brain metastasis has been recognized as one of the central issues in breast cancer research. Elucidation of the process and pathway that mediate this step is expected to provide important clues for a better understanding of breast cancer metastasis. Increasing evidence suggests that th...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010506 | Pride
Integrative omics analysis Glycomics Transcriptomics Proteomics Breast cancer brain metastasis 
ProteomicsThe mechanism of TRIM21 inhibiting the invasion and migration of ccRCC by stabilizing ASS1
Clear cell renal cell carcinoma (ccRCC) is characterized by its aggressive invasion and metastasis, posing significant clinical challenges. Understanding the molecular mechanisms underlying its progression is crucial for developing effective therapeutic strategies. The role of TRIM21 in regulating A...
ORGANISM(S): Homo Sapiens 
2024-08-13 | PXD054847 |
GenomicsA PTIP-PA1 subcomplex promotes transcription for IgH class-switching independently from the associated MLL3/MLL4 methyltransferase complex
Class-switch recombination (CSR) diversifies antibodies for productive immune responses while maintaining stability of the B cell genome. Transcription at the immunoglobulin heavy-chain (Igh) locus targets CSRassociated DNA damage and is promoted by the BRCT domain-containing PTIP protein. Although ...
ORGANISM(S): Mus musculus 
2015-12-12 | E-GEOD-75930 | biostudies-arrayexpress
UnknownFine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
Not available
S-EPMC3036586 | biostudies-literature
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