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ProteomicsCancer-associated Notch receptor variants lead to O-fucosylation defects that can deregulate Notch signaling
NOTCH1 is a transmembrane receptor that initiates the Notch signaling pathway involved in embryonic development and maintenance of adult tissue homeostasis. The extracellular part of NOTCH1 is composed largely of EGF-like domains (EGFs) many of which can be O-fucosylated by protein O-fucosyltransfer...
ORGANISM(S): Homo sapiens (Human) 
2022-10-21 | PXD036345 | Pride
O-fucosylation Egf repeat Cancer Notch Pofut1 
ProteomicsModulation of the NOTCH1 pathway by LUNATIC FRINGE is dominant over that of MANIC or RADICAL FRINGE
Fringes are glycosyltransferases that transfer a GlcNAc to O-fucose residues on Epidermal Growth Factor-like (EGF) repeats. Three Fringes exist in mammals: LUNATIC FRINGE (LFNG), MANIC FRINGE (MFNG) and RADICAL FRINGE (RFNG). Fringe modification of O-fucose on EGF repeats in the NOTCH1 (N1) extracel...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-28 | PXD027619 | Pride
O-fucosylation Glycosylation Notch1 Fringe Egf-like domains 
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