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ProteomicsPupylation-independent substrate recruitment to proteasomal degradation in mycobacteria
Mycobacteria and other Actinobacteria possess proteasomal degradation pathways in addition to the common bacterial compartmentalizing protease systems. Proteasomal degradation supports survival of these bacteria in adverse environments and conditions. The mycobacterial proteasome interacts with mult...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2023-08-04 | PXD039021 | Pride
Heat shock Mycobacteria Quality control Proteasomal degradation 
ProteomicsIn situ analysis of osmolyte mechanisms of proteome thermal stabilisation
Organisms across all kingdoms of life use small organic molecules called osmolytes to adapt to diverse environmental conditions and preserve viability. Osmolytes are thought to thermally stabilise proteins based on in vitro studies of a few purified proteins. The molecular mechanisms of osmolytes re...
ORGANISM(S): Escherichia coli 
2024-08-09 | PXD036186 | Pride
Osmolyte mechanisms Structural proteomics Stress adaptation Thermal stabilisation Aggregation 
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