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MetabolomicsMapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
Polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) hybrid systems typically use complex protein-protein interactions to facilitate direct transfer of intermediates between these multimodular megaenzymes. In the canal-associated neurons (CANs) of Caenorhabditis elegans, PKS-1 and NR...
2021-06-22 | MTBLS2313 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis reveals Flg22 regulates MAP kinase 6 interaction with an ethylene response factor substrate via ethylene
Despite their importance, plant MAP kinase targets are still poorly elucidated. Here, the specific in vivo interaction of an ethylene response factor (ERF104) with the Arabidopsis MAP kinase, MPK6, is shown by fluorescence resonance energy transfer. The interaction, which is lost within minutes afte...
ORGANISM(S): Arabidopsis thaliana 
2009-05-27 | E-GEOD-11807 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles in a Rabbit Model of Systemic Lupus Erythematosus
We previously reported the establishment of a rabbit (Oryctolagus cuniculus) model of Systemic Lupus Erythematosus (SLE) in which peptide immunization led to lupus-like autoantibody production including anti-Sm, -RNP, -SS-A, -SS-B and -dsDNA. Some neurological symptoms in form of seizures and nystag...
ORGANISM(S): Oryctolagus cuniculus 
2010-07-23 | E-GEOD-23076 | biostudies-arrayexpress
TranscriptomicsComparison of C3 or C3156-181-peptide treated Isolated primary rat neonatal Sschwann Cells after 72 h
The aim of this study was to identify differently expressed genes between C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells. To elucidate the unresolved mechanism behind the promoting effect of C3156-181 on PNR we cultured primary rat neonatal SCs and treated them for up to...
ORGANISM(S): Rattus norvegicus 
2015-07-11 | E-GEOD-70748 | biostudies-arrayexpress
TranscriptomicsComparison of C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells after 12 h
The aim of this study was to identify differently expressed genes between C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells. To elucidate the unresolved mechanism behind the promoting effect of C3156-181 on PNR we cultured primary rat neonatal SCs and treated them for up to...
ORGANISM(S): Rattus norvegicus 
2015-07-11 | E-GEOD-70747 | biostudies-arrayexpress
TranscriptomicsInhibition of Tumor Growth and Metastasis by EMMPRIN Multiple Antigenic Peptide (MAP) Vaccination Is Mediated by Immune Modulation
We report here that a EMMPRINs-specific cancer peptide vaccination, where the peptide was modified and synthesied as a multiple antigenic peptide (MAP), significantly inhibited tumor growth and metastases. Specifically, we describe changes in the gene expression profile as assessed by RNAseq in tumo...
ORGANISM(S): Mus musculus 
2019-08-06 | GSE85440 | GEO
TranscriptomicsMatA S. cerevisiae cells exposed to Iztli peptide 1 for 3.5, 7, 15 and 30 minutes
Transcriptional profiling of MatA yeast cells exposed to a cationic antimicrobial peptide (Iztli peptide 1) for 3.5, 7, 15 and 30 min is compared with MatA yeast cells without the peptide Two-condition experiment, MatA cells with peptide (P) and without it (C). Biological samples: 4 control, 4 treat...
ORGANISM(S): Saccharomyces cerevisiae 
2016-06-28 | E-GEOD-83746 | biostudies-arrayexpress
ProteomicsConfetti: A Multi-protease Map of the HeLa Proteome for Comprehensive Proteomics
Tryptic digestion proteomics gives limited coverage of many protein sequences as many proteins produce tryptic peptides that cannot be observed easily. Confetti is our comprehensive map of coverage for the HeLa proteome, using 48 different digests and CID/HCD LC-MS/MS analyses. An associated dataset...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-10-12 | MSV000081607 | MassIVE
ProteomicsHigh-throughput discovery of Chagas Disease antigens and their linear B-cell epitopes using high-density peptide arrays
Screening of antibody-binding specificities from pooled normal (healthy) and chronic Chagas Disease patients.
ORGANISM(S): Homo sapiens 
2015-06-24 | E-MTAB-3008 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression regulation in murine hearts treated with an ERK-dimerization inhibitory peptide gene therapy or control after transverse aortic constriction
This study identifies gene expression changes in murine hearts after TAC surgery and in response to gene therapy with ERK-dimerization inhibitory peptide
ORGANISM(S): Mus musculus 
2020-02-03 | E-MTAB-8110 | biostudies-arrayexpress
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