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ProteomicsCoisolation of peptide pairs for peptide identification and MS/MS-based quantification
SILAC-based metabolic labeling is a widely adopted proteomics approach that enables quantitative comparisons among a variety of experimental conditions. Despite its quantitative capacity, SILAC experiments analyzed with data dependent acquisition (DDA) do not fully leverage peptide pair information ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-11-03 | PXD033016 | Pride
Ms/ms Yeast Silac Peptide pairs Quantification Comet 
TranscriptomicsCollagen-binding C-type natriuretic peptide enhances chondrogenesis and osteogenesis
To enhance local drug delivery and therapeutic efficacy, we developed a novel synthetic protein by fusing a collagen-binding domain (CBD) to C-type natriuretic peptide (CNP), termed CBD-CNP. CBD-CNP localized to collagen-rich tissues and promoted bone elongation.
ORGANISM(S): Mus musculus 
2025-12-05 | E-MTAB-16154 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila abdomen from females mated with sex peptide null or sex peptide producing males
Comparison of females mated to males null for Sex-Peptide (SP0, Liu, H. and E. Kubli, Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster. Proc Natl Acad Sci U S A, 2003. 100(17): p. 9929-33) or to control, Sex-Peptide producing, males. Comparisons were made at 3 and 6 ...
ORGANISM(S): Drosophila melanogaster 
2009-08-01 | E-MEXP-2074 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Drosophila head and thorax from females mated with sex peptide null or sex peptide producing males
Comparison of females mated to males null for Sex-Peptide (SP0, Liu, H. and E. Kubli, Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster. Proc Natl Acad Sci U S A, 2003. 100(17): p. 9929-33) or to control, Sex-Peptide producing, males. Comparisons were made at 3 and 6 ...
ORGANISM(S): Drosophila melanogaster 
2009-08-01 | E-MEXP-2070 | biostudies-arrayexpress
ProteomicsEffect of Phosphorylation on the Collision Cross Sections of Peptide Ions in Ion Mobility Spectrometry
The insertion of ion mobility spectrometry (IMS) between LC and MS can improve peptide identification in both proteomics and phosphoproteomics by providing structural information that is complementary to LC and MS, because IMS separates ions on the basis of differences in their shapes and charge sta...
ORGANISM(S): Homo Sapiens (human) 
2021-01-14 | PXD019746 | JPOST Repository
ProteomicsComplementary CID and 351 nm UVPD tandem mass spectra enable effective de novo sequencing
This dataset accompanies a publication in which we present a strategy for acquisition and effective de novo peptide sequencing of complementary CID and 351 nm ultraviolet photodissociation (UVPD) MS/MS pairs. E. coli whole cell lysate is carbamylated to block lysine side chains, digested with trypsi...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2017-03-06 | MSV000080603 | MassIVE
UnknownCoisolation of Peptide Pairs for Peptide Identification and MS/MS-Based Quantification.
Not available
S-EPMC9851627 | biostudies-literature
TranscriptomicsTargeting MDM4/MDM2 binding interface for reactivation of p53 in cancer therapy
The aim of this experiment has been to investigate the transcriptional profile of HCT116 cells treated with Peptide-3 (Pep3) compared to untreated (NT), treated with solvent (DMSO) or with a mutated peptide (Pep3M) cells. Peptide-3 is a dodecapeptide able to interact with MDM2 at the levels of the i...
ORGANISM(S): Homo sapiens 
2017-04-18 | E-GEOD-62855 | biostudies-arrayexpress
ProteomicsIonmob: A Python Package for Prediction of Peptide Collisional Cross-Section Values
Motivation: Including ion mobility separation (IMS) into mass spectrometry proteomics experiments is useful to improve coverage and throughput. Many IMS devices enable linking experimentally derived mobility of an ion to its collisional cross-section (CCS), a highly reproducible physicochemical pro...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2023-09-21 | PXD043026 | JPOST Repository
ProteomicsChimeric design of Pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA pairs for genetic code expansion
An orthogonal aminoacyl-tRNA synthetase/tRNA pair is a key prerequisite for site-specific incorporation of unnatural amino acids. Due to its high codon suppression efficiency and full orthogonality, the pyrrolysyl-tRNA synthetase/pyrrolysyl-tRNA pair is currently the ideal system for genetic code ex...
ORGANISM(S): Escherichia coli 
2020-05-25 | PXD018660 | Pride
Chimeric design Genetic code expansion 
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