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MetabolomicsPlant elicitor peptide signalling confers rice resistance to piercing-sucking insect herbivores and pathogens
Rice is a staple food crop worldwide, and its production is severely threatened by phloem-feeding insect herbivores, particularly the brown planthopper (BPH, Nilaparvata lugens), and destructive pathogens. Despite the identification of many BPH resistance genes, the molecular basis of rice resistanc...
2022-02-23 | MTBLS3518 | MetaboLights
MetabolomicsProteolytic-Resistant Self-Assembling Peptide Nanofibers Combat Specific Bacterial Infections via Trap-and-Kill

The rise in global antibiotic resistance highlights the urgent need for effective antimicrobial agents. Antimicrobial peptides (AMPs) offer a potential solution to combat bacterial resistance. However, key challenges remain in addressing the limitations of current peptide drugs and biomaterials, ...

2025-06-13 | MTBLS12424 | MetaboLights
TranscriptomicsRegulatory consequences of TARBP2 knock-down in MDA-LM2 cell-line [stability experiment]
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant increase in the stability of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic MDA-LM2 cells. The cells were then subjected to whole...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-49612 | biostudies-arrayexpress
UnknownComparison of a Short Linear Antimicrobial Peptide with Its Disulfide-Cyclized and Cyclotide-Grafted Variants against Clinically Relevant Pathogens.
Not available
S-EPMC8228819 | biostudies-literature
ProteomicsIdentification of phosphosites that alter protein thermal stability
We developed a robust method termed Dali that identifies phosphorylation events that alter protein thermal stability as a proxy for function.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-06-18 | PXD016750 | Pride
Proteomics Function Thermal stability Phosphorylation Dali 
TranscriptomicsReliability and stability of individual differences in gene expression
Studying the causes and correlates of natural variation in gene expression in healthy populations assumes that individual differences in gene expression can be reliably and stably assessed across time. However, this is yet to be established. We examined 4-hour test-retest reliability and 10 month te...
ORGANISM(S): Homo sapiens 
2009-02-28 | E-GEOD-14844 | biostudies-arrayexpress
ProteomicsDigestion time course of human liver plasma membrane
The selection of signature peptides is critical for reliable peptide quantification. The purpose of this study was to comprehensively assess the digestion efficiency and stability of tryptic peptides and to identify optimal signature peptides for human hepatic transporters and membrane marker protei...
ORGANISM(S): Homo Sapiens (human) 
2022-10-12 | PXD034402 | JPOST Repository
TranscriptomicsTranscription profiling of mouse dermal fibroblasts following exposure to endothelin-1
To determine if aberrant activation of endothelin-1 (Et1) could lead to the dysregulation of many downstream genes, we exposed fibroblasts to exogenous ET1 peptide and assayed for transcriptional changes by microarray. Mouse dermal fibroblasts were treated with exogenous Et1 peptide for 24 hours. ...
ORGANISM(S): Mus musculus 
2007-06-29 | E-GEOD-4695 | biostudies-arrayexpress
ProteomicsStability assessment of the human proteotypic peptides for proteomics quantification
Mass spectrometry coupled to liquid chromatography is one of the most powerful technologies for proteome quantification in a variety of biomedical samples, including cells, tissues and liquid biopsies. In peptide-centric workflows protein mixtures proteins are enzymatically digested to peptides prio...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD035198 | Pride
Proteotypic Proteome tools Peptide stability Quantitation 
UnknownCyclization of the Analgesic α-Conotoxin Vc1.1 With a Non-Natural Linker: Effects on Structure, Stability, and Bioactivity.
Not available
S-EPMC12010462 | biostudies-literature
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