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ProteomicsClinical Proteomics of Breast Cancer Unravels a Novel Layer of Breast Cancer Classification
Breast cancer classification has been in the focus of numerous large worldwide efforts, analyzing the molecular basis of breast cancer subtypes, aiming to associate them with clinical outcome and improve the current diagnostic routine. Genomic and transcriptomic profiles of breast cancer have been w...
ORGANISM(S): Homo sapiens (Human) 
2019-07-29 | PXD009766 | Pride
Lc-ms Proteomics Breast cancer classification Breast cancer subtypes 
TranscriptomicsEZH2 promotes a bi-lineage identity in basal-like breast cancer cells
The mechanisms regulating breast cancer differentiation state are poorly understood. Of particular interest are molecular regulators controlling the highly aggressive and poorly differentiated traits of basal-like breast carcinomas. Here we show that the Polycomb factor EZH2 maintains the differenti...
ORGANISM(S): Homo sapiens 
2012-09-21 | E-GEOD-36939 | biostudies-arrayexpress
TranscriptomicsDetermination of molecular markers for BRCA1 and BRCA2 heterozygosity using gene expression profiling
Approximately 5% of all breast cancers can be attributed to an inherited mutation in one of two cancer susceptibility genes, BRCA1 and BRCA2. We searched for genes that have the potential to distinguish healthy BRCA1 and BRCA2 mutation carriers from non-carriers based on differences in expression pr...
ORGANISM(S): Homo sapiens 
2013-01-10 | E-GEOD-39976 | biostudies-arrayexpress
TranscriptomicsControl of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3
Regulatory factors controlling stem cell identity and self-renewal are often active in aggressive cancers and are thought to promote their growth and progression. TCF3 (also known as TCF7L1) is a member of the TCF/LEF transcription factor family that is central in regulating epidermal and embryonic ...
ORGANISM(S): Homo sapiens 
2012-10-23 | E-GEOD-38893 | biostudies-arrayexpress
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