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ProteomicsOf mice and models: Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer
- Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, whi...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD054649 | Pride
Proteogenomics Proteomics Mass spectrometry Patient-derived xenograft models (pdx) Ovarian cancer 
ProteomicsProteomic analysis reveals low dose PARP inhibitor-induced differential protein expression in BRCA1-mutated high-grade serous ovarian cancer cells
To detect the off-target effects of PARP inhibition, a quantitative mass spectrometry-based proteomic analysis was conducted of a BRCA1-mutated HGSOC cell line treated with low doses of two PARPi, Niraparib and Rucaparib.
ORGANISM(S): Homo sapiens (Human) 
2022-04-15 | PXD027177 | Pride
Proteomics Ovarian cancer Mass spectrometry Tandem mass tags (tmt) Parp inhibitor (parpi) 
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