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ProteomicsShared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice.
Despite the diverse genetic origins of autism spectrum disorders (ASDs), affected individuals share strikingly similar and correlated behavioural traits that include perceptual and sensory processing challenges. Notably, the severity of these sensory symptoms is often predictive of the expression of...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-15 | PXD051022 | Pride
Setd5 Superior coliculus Sensorimotor transformation Periaqueductal grey 
TranscriptomicsTranscription profiling of mouse brain regions (bed nucleus of the stria terminalis, hippocampus, hypothalamus, periaqueductal gray, and pituitary gland) in six mouse strains (129S6/SvEvTac, A/J, C57BL/6J, C3H/HeJ, DBA/2J, and FVB/NJ)
Gene expression patterns were determined from five brain regions (bed nucleus of the stria terminalis, hippocampus, hypothalamus, periaqueductal gray, and pituitary gland) in six mouse strains (129S6/SvEvTac, A/J, C57BL/6J, C3H/HeJ, DBA/2J, and FVB/NJ). At least two replicate samples per brain regio...
ORGANISM(S): Mus musculus 
2009-09-16 | E-GEOD-4734 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of mouse periaqueductal gray (PAG) neurons using Smart-seq2.
We optimized Voltage-Seq which combines, all-optical physiology, spatial mapping, on-site classification, and RNA-transcriptomics to robustly increase the throughput of synaptic connectivity testing and targeted molecular classification of postsynaptic neurons. Single-cell RNA-sequencing was perform...
ORGANISM(S): Mus musculus 
2023-06-22 | E-MTAB-13104 | biostudies-arrayexpress
UnknownThe ventrolateral periaqueductal grey updates fear via positive prediction error.
Not available
S-EPMC6995762 | biostudies-literature
UnknownNeural substrates underlying fear-evoked freezing: the periaqueductal grey-cerebellar link.
Not available
S-EPMC4027863 | biostudies-literature
UnknownBidirectional control of fear memories by cerebellar neurons projecting to the ventrolateral periaqueductal grey.
Not available
S-EPMC7566591 | biostudies-literature
UnknownCerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour.
Not available
S-EPMC8923669 | biostudies-literature
UnknownFunctional subdivision of the human periaqueductal grey in respiratory control using 7 tesla fMRI.
Not available
S-EPMC4441042 | biostudies-literature
UnknownParacetamol is a centrally acting analgesic using mechanisms located in the periaqueductal grey.
Not available
S-EPMC7070177 | biostudies-literature
UnknownDifferential Encoding of Predator Fear in the Ventromedial Hypothalamus and Periaqueductal Grey.
Not available
S-EPMC7687061 | biostudies-literature
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