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ProteomicsSETD5 regulates the OGT-catalyzed O-GlcNAcylation of RNA polymerase II, which is involved in the stemness of colorectal cancer cells
The dosage-dependent recruitment of RNA polymerase II (Pol II) at the promoters of genes related to neurodevelopment and stem cell maintenance is required for transcription by the fine-tuned expression of SET-domain-containing protein 5 (SETD5). Pol II O-GlcNAcylation by O-GlcNAc transferase (OGT) i...
ORGANISM(S): Homo sapiens (Human) 
2023-11-16 | PXD041141 | Pride
O-glcnac Setd5 Colorectal cancer 
TranscriptomicsTranscriptional profiling of Setd5 heterozygous and knockout mouse embryonic stem cells
SET-domain containing proteins play a vital role in regulating gene expression during development through modifications in chromatin structure. To study molecular function of SET domain containing 5 (Setd5), we assessed global changes in the mouse embryonic stem cell transcriptome when Setd5 gene i...
ORGANISM(S): Mus musculus 
2016-12-13 | E-MTAB-5189 | biostudies-arrayexpress
ProteomicsShared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice.
Despite the diverse genetic origins of autism spectrum disorders (ASDs), affected individuals share strikingly similar and correlated behavioural traits that include perceptual and sensory processing challenges. Notably, the severity of these sensory symptoms is often predictive of the expression of...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-15 | PXD051022 | Pride
Setd5 Superior coliculus Sensorimotor transformation Periaqueductal grey 
GenomicsSetd5 Coordinates Motor Neuron Development and Locomotor Function
Setd5 Coordinates Motor Neuron Development and Locomotor Function
PRJNA1511185 | ENA
GenomicsTranscriptional profiling of Setd5 mutant cortical tissue
Transcriptional profiling of Setd5 mutant cortical tissue
PRJNA549931 | ENA
GenomicsExpression data from SETD5-expressing 3T3-L1 cells.
Expression data from SETD5-expressing 3T3-L1 cells.
PRJNA762098 | ENA
GenomicsSETD5 haploinsufficiency affects mitochondrial compartment in neural cells
SETD5 haploinsufficiency affects mitochondrial compartment in neural cells
PRJNA918428 | ENA
GenomicsNext generation sequencing in SETD5-depleted Huh7 cells.
Next generation sequencing in SETD5-depleted Huh7 cells.
PRJNA796218 | ENA
UnknownSETD5 in glioma cells conferred TRAIL resistance induction.
Not available
S-EPMC12479859 | biostudies-literature
TranscriptomicsSetd5 Coordinates Motor Neuron Development and Locomotor Function
Epigenetic regulation is essential for cell fate determination, yet its role in spinal motor neuron (MN) development remains poorly understood. SETD5, an epigenetic regulator, is mutated in SETD5 syndrome, which is characterized by intellectual disability and motor dysfunction. However, the mechanis...
ORGANISM(S): Mus musculus 
2026-08-11 | GSE343297 | GEO
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