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MetabolomicsLarge neutral amino acid levels tune perinatal neuronal excitability and survival
Surprisingly little is known about the critical metabolic changes that neural cells have to undergo during development and how even mild, temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically-...
2023-03-28 | MTBLS6578 | MetaboLights
MetabolomicsIntergenerational Association of Gut Microbiota and Metabolism with Perinatal Folate Metabolism and Neural Tube Defects (Feces metabolomics)

Maternal folic acid intake is crucial for the development of the offspring's nervous system, and folic acid metabolism disorders during pregnancy lead to neural tube defects (NTDs) in the fetus. Folic acid and vitamins biosynthesis is a major biochemical feature of gut microbiota. The complex and...

2022-12-05 | MTBLS4893 | MetaboLights
MetabolomicsIntergenerational Association of Gut Microbiota and Metabolism with Perinatal Folate Metabolism and Neural Tube Defects (Brain tissue metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-12-05 | MTBLS4894 | MetaboLights
TranscriptomicsFunctional genomics in perinatal asphyxia and fetal asphyctic preconditioning in the brain
Fetal asphyctic (FA) preconditioning is effective in attenuating brain damage incurred by a subsequent perinatal asphyctic insult. Unraveling mechanisms of this endogenous neuroprotection, activated by FA preconditioning, is an important step towards new clinical strategies for asphyctic neonates. G...
ORGANISM(S): Rattus norvegicus 
2014-12-22 | E-GEOD-42676 | biostudies-arrayexpress
MetabolomicsPerinatal DDT causes dysfunctional lipid metabolism underlying metabolic syndrome
Not available
ORGANISM(S): Homo sapiens 
ST000122 | MetabolomicsWorkbench
MetabolomicsDysfunctional lipid metabolism underlies the effect of perinatal DDT exposure on the development of metabolic syndrome
Not available
ORGANISM(S): Mus musculus 
ST000095 | MetabolomicsWorkbench
MetabolomicsDysfunctional lipid metabolism underlies the effect of the perinatal DDT exposure on the development of metabolic syndrome
Not available
ORGANISM(S): Mus musculus 
ST000597 | MetabolomicsWorkbench
MetabolomicsDysfunctional lipid metabolism underlies the effect of the perinatal DDT exposure on the development of metabolic syndrome (part II)
Not available
ORGANISM(S): Mus musculus 
ST000598 | MetabolomicsWorkbench
TranscriptomicsParkin-mediated mitophagy evokes perinatal cardiac mitochondria maturation
Exclusion of Parkin from mitochondria of perinatal cardiomyocytes interrupts structural and molecular transformations essential to normal perinatal-adult mitochondrial replacement. mRNA-sequencing from cardiac total RNA was performed at P1, P21 and 5-week stages of nontransgenic (ntg) and human-Mfn2...
ORGANISM(S): Mus musculus 
2015-12-04 | E-GEOD-68921 | biostudies-arrayexpress
GenomicsThe Jerusalem Perinatal Study
The Jerusalem Perinatal Study (JPS) aimed to examine the developmental origins of cardiometabolic risk.
EGAD00010001816 | EGA
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