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MetabolomicsOral dysbiosis initiates periodontal disease in experimental kidney disease

BACKGROUND AND HYPOTHESIS: It is presently unclear why there is a high prevalence of periodontal disease in individuals living with chronic kidney disease. Whilst some have argued that periodontal disease causes chronic kidney disease, we hypothesized that alterations in saliva ...

2025-09-04 | MTBLS1833 | MetaboLights
TranscriptomicsComparative gene expression analysis of dental follicle and periodontal ligament in humans
The aim of this study was to evaluate and compare the gene expression profiles of dental follicle and periodontal ligament in humans, which can possibly explain their functions of dental follicle and PDL such as eruption coordination and stress resorption. That may apply this information to clinical...
ORGANISM(S): Homo sapiens 
2014-08-21 | E-GEOD-51342 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood monocytes in periodontal therapy
Periodontal infections have been associated with systemic inflammation and risk for atherosclerosis and vascular disease. We investigated the effects of comprehensive periodontal therapy on gene expression of peripheral blood monocytes. Approximately 1/3 of the patients showed substantial changes in...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6751 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed long noncoding RNA expression between periodontal ligament stem cells from healthy periodontal tissue and periodontal ligament stem cells from inflammatory periodontal tissue.
Periodontitis can impair the osteogenic differentiation of human periodontal mesenchymal stem cells, but the underlying molecular mechanisms are still poorly understood. Long noncoding RNAs (lncRNAs) have been demonstrated to play significant roles under both physiologic and pathological conditions....
ORGANISM(S): Homo sapiens 
2016-02-19 | E-GEOD-78074 | biostudies-arrayexpress
TranscriptomicsComparative gene expression analysis of the human periodontal ligament in deciduous and permanent teeth
There are histological and functional differences between human deciduous and permanent pediodontal ligament (PDL) tissues. The purpose of this study was to determine the differences between these two types of tissue at the molecular level by comparative gene expression analysis. PDL samples were ob...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-50640 | biostudies-arrayexpress
Transcriptomics48-h stretched human periodontal ligament cells
Human periodontal ligament (HPDL) is continuously exposed to mechanical stress in vivo. In this study, in utilizing DNA chips, we analyzed the influences of mechanical stress on the gene expression profile of HPDL cells in vitro. HPDL cells were obtained from extracted first premolars of individuals...
ORGANISM(S): Homo sapiens 
2010-06-19 | E-GEOD-19118 | biostudies-arrayexpress
TranscriptomicsThe microRNA profile of human periodontal ligament-derived stem cells subjected to dynamic tensile strain
This study aimed to investigate the microRNA expression profile of mechnically strained human periodontal ligament-derived stem cells, and SurePrint G3 Human v16 miRNA Array (Agilent) was employed as a screening platform. We discovered 39 differentially expressed microRNAs between the stretched and ...
ORGANISM(S): Homo sapiens 
2014-09-28 | E-GEOD-41337 | biostudies-arrayexpress
TranscriptomicsEffect of FDC-SP on Gene Expression of Human Periodontal Ligament Cells
Previous research has reported that FDC-SP had similar molecular properties to statherin, a protein exists in saliva which plays important roles in preventing Ca precipitation. Further biomolecular study has suggested that the expression of FDC-SP may be associated with periodontal ligament (PDL) ph...
ORGANISM(S): Homo sapiens 
2014-09-13 | E-GEOD-61384 | biostudies-arrayexpress
UnknownLong-term assessment of periodontal disease progression after surgical or non-surgical treatment: a systematic review.
Not available
S-EPMC6494769 | biostudies-literature
ProteomicsSARS-CoV-2 infection causes periodontal fibrotic pathogenesis through deregulating mitochondrial beta-oxidation
The global high prevalence of COVID-19 is a major challenge for health professionals and patients. SARS-CoV-2 virus has four kinds of structural protein components: the spike protein, envelope protein, membrane protein, and nucleocapsid protein. SARS-CoV-2 virus mutate predominantly in the spike pro...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041281 | Pride
Covid19 Periodontal Infection 
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