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TranscriptomicsTranscription profiling of mouse at ages P4 and P60 in sciatic nerve of wild type and with peripheral neuropathies to study disease mechanisms in peripheral neuropathies due to altered Pmp22 gene dosage or a Pmp22 point mutation
We compared gene expression at ages P4 and P60 in sciatic nerve of wild type mice and mice with peripheral neuropathies caused by altered Pmp22 gene dosage (homozygous knockout or transgene) or a point mutation (Trembler).
ORGANISM(S): Mus musculus 
2007-11-03 | E-GEOD-1947 | biostudies-arrayexpress
UnknownPeripheral myelin protein 22 alters membrane architecture.
Not available
S-EPMC5498104 | biostudies-literature
UnknownReversible folding of human peripheral myelin protein 22, a tetraspan membrane protein.
Not available
S-EPMC3762913 | biostudies-literature
TranscriptomicsImmunodominant myelin basic protein fragments induce mechanical hypersensitivity.
An insulating myelin sheath ensures saltatory conduction of mechanosensory A afferents. Myelin damage results in the electrical instability of A fibers and the ability to generate pain in response to light touch/pressure (mechanical allodynia). We have hypothesized and then established that the re...
ORGANISM(S): Rattus norvegicus 
2012-03-03 | E-GEOD-34868 | biostudies-arrayexpress
UnknownHow T118M peripheral myelin protein 22 predisposes humans to Charcot-Marie-Tooth disease.
Not available
S-EPMC9860121 | biostudies-literature
UnknownPeripheral Myelin Protein 22 Gene Mutations in Charcot-Marie-Tooth Disease Type 1E Patients.
Not available
S-EPMC9321036 | biostudies-literature
UnknownColocalization Analysis of Peripheral Myelin Protein-22 and Lamin-B1 in the Schwann Cell Nuclei of Wt and TrJ Mice.
Not available
S-EPMC8946543 | biostudies-literature
ProteomicsGlycosylation Limits Forward Trafficking of the Tetraspan Membrane Protein PMP22
Peripheral myelin protein 22 (PMP22) is a tetraspan integral membrane protein for which mistrafficking-causing mutations are linked to the inherited peripheral neuropathy, Charcot-Marie-Tooth disease (CMTD). Wild type (WT) PMP22 is an inefficient folder with ~20% of the protein trafficking to the pl...
ORGANISM(S): Homo sapiens (Human) 
2021-04-27 | PXD023091 | Pride
Charcot-marie-tooth disease Protein quality control Peripheral myelin protein 22 Quantitative proteomics Proteostasis Protein folding 
UnknownRer1 and calnexin regulate endoplasmic reticulum retention of a peripheral myelin protein 22 mutant that causes type 1A Charcot-Marie-Tooth disease.
Not available
S-EPMC4227013 | biostudies-literature
UnknownPeripheral myelin protein 22 modulates store-operated calcium channel activity, providing insights into Charcot-Marie-Tooth disease etiology.
Not available
S-EPMC6690708 | biostudies-literature
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