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UnknownQuantitative Assessment of Early [18F]Sodium Fluoride Positron Emission Tomography/Computed Tomography Response to Treatment in Men With Metastatic Prostate Cancer to Bone.
Not available
S-EPMC5562173 | biostudies-literature
ProteomicsChemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides
The stress sensors ATF6, IRE1 and PERK monitor deviations from homeostatic conditions in the endoplasmic reticulum (ER), a protein biogenesis compartment of eukaryotic cells. Their activation elicits unfolded protein responses (UPR) to re-establish proteostasis. UPR have been extensively investigate...
ORGANISM(S): Homo sapiens (Human) 
2018-02-16 | PXD008529 | Pride
Proteomics Endoplasmic reticulum stress (er stress) Endoplasmic reticulum (er) Transcriptomics Proteostasis Unfolded protein response (upr) 
ProteomicsSoluble SORLA enhances neurite outgrowth and regeneration through activation of EGFR and MAPK pathways
SORLA is a type I transmembrane component associated with Alzheimers disease (AD) risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain yet unclear. Here, we show that cultured neurons overexpressing SORLA (SORLA TG) feature enhanced neurite length, and accele...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-05-12 | MSV000085400 | MassIVE
GenomicsFGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency
Genome-wide erasure of DNA methylation takes place in primordial germ cells (PGCs) and early embryos but the signalling mechanisms that induce reprogramming are unknown. Here we show that inhibition of Erk1/2 and Gsk3bM-BM- signalling in mouse embryonic stem cells (ESCs) by small molecule inhibitors...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-42923 | biostudies-arrayexpress
TranscriptomicsInhibition of MEK and PI3K alone or in combination alters the transcriptome of the lung during TGF?-induced pulmonary fibrosis
Pulmonary fibrosis is often triggered by an epithelial injury resulting in the formation of fibrotic lesions in the lung, which progress to impair gas exchange and ultimately cause death. Recent clinical trials using drugs that target either inflammation or a specific molecule have failed, suggestin...
ORGANISM(S): Mus musculus 
2013-12-03 | E-GEOD-52854 | biostudies-arrayexpress
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