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ProteomicsEndosomal cAMP production impacts the broad cellular phosphoproteome
Endosomal signaling from G protein-coupled receptors (GPCRs) has emerged as a novel paradigm with important pharmacological and physiological implications. Yet, our knowledge of the functional consequences of activating intracellular GPCRs is incomplete. To address this gap, we combined an optogenet...
ORGANISM(S): Homo sapiens (Human) 
2021-06-15 | PXD025775 | Pride
Camp- cyclic amp  bpac- bacterial photoactivatable adenylyl cyclase Gpcr- g protein-coupled receptor  silac- stable isotope labeling with amino acids in cell culture  fe3+-nta imac- iron (iii)-nitrilotriacetic acid immobilized metal ion affinity  lc-ms/ms- liquid chromatography-tandem mass spectrometry  pka- protein kinase a  pde- phosphodiesterase  pp2a- protein phosphatase 2a 
TranscriptomicsDevelopment and Validation of a Novel Molecular Biomarker Diagnostic Test for the Early Detection of Sepsis
Introduction: Sepsis is a complex immunological response to infection characterized by early hyperinflammation followed by severe and protracted immunosuppression, suggesting that a multi-marker approach has the greatest clinical utility for early detection, within a clinical environment focused on ...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-28750 | biostudies-arrayexpress
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