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TranscriptomicsExpression analysis of mouse embryonic stem cell (mESC) derived neuronal cell-types
The generation of specific types of neurons from stem cells offers important opportunities in regenerative medicine. However, future applications and proper verification of cell identities will require stringent ways to generate homogenous neuronal cultures. Here we show that under permissive cultur...
ORGANISM(S): Mus musculus 
2011-03-04 | E-GEOD-27655 | biostudies-arrayexpress
TranscriptomicsNurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons
Nurr1 (Nr4a2, nuclear receptor subfamily 4 group A member 2) is needed for the development of ventral midbrain dopaminergic neurons, and has been associated with Parkinson's disease. We used mice where the Nurr1 gene is ablated by tamoxifen treatment selectively in dopaminergic neurons. As a control...
ORGANISM(S): Mus musculus 
2013-01-14 | E-GEOD-42912 | biostudies-arrayexpress
TranscriptomicsComparison of GFP- and Nurr1-infected ES-cell derived neurons
ES cell-derived neurons of forebrain identity were isolated by magnetic sorting, cultured for 7 days and transduced with either Nurr1 or eGFP lentivirus. After an additional 12 h in culture, mRNA was isolated and subjected to microarray analysis. The raw data have been provided in CEL format The p...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-20392 | biostudies-arrayexpress
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