Sort   by:  
 Page size 
MetabolomicsIntegrated Analyses of the Gut Microbiota, Intestinal Permeability and Serum Metabolome Phenotype in Rats with Alcohol Withdrawal Syndrome
The etiology of alcohol dependence is not completely understood. Increasing evidence reveals that gut microbiota dysbiosis is associated with certain psychiatric disorders, including alcoholism, through the 'microbiota-gut-brain' axis. The aims were to evaluate the effect of alcohol abuse on the gut...
2021-07-30 | MTBLS2688 | MetaboLights
MetabolomicsAspartate potentiates tobramycin against multidrug-resistant Edwardsiella tarda through enhancing proton motive force and membrane permeability

The antibiotic susceptibility/resistance of bacteria is influenced by their metabolic states. In tobramycin-resistant Edwardsiella tarda (LTB4-RToB), a dynamic metabolic state is observed, characterized by a general reduction in most metabolites as the minimum inhibitory concentration (MIC) incre...

2025-07-31 | MTBLS12725 | MetaboLights
TranscriptomicsSlit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle by inducing capillary sprouting and decreasing vascular permeability via reduced eNOS activity
Rationale: Slit2 is a possible modulator of vascular endothelial growth factor (VEGF) - induced angiogenesis, but its effects have not been tested in large animal models. Objective: We studied the effect of Slit2 on therapeutic angiogenesis induced by VEGF receptor 2 (VEGFR2) ligands Vammin and VEGF...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-63283 | biostudies-arrayexpress
ModelsMenichetti2019 - Drug−Membrane Permeability across Chemical Space
Using Coarse Grained (CG) models, where several atoms are aggregated into a single bead, the authors obtain a set of 500,000 compounds with their simulated permeability across a single-component DOPC lipid bilayer. With this approach, the authors are able to cover a large and representative portion ...
2024-08-07 | MODEL2408070001 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
ModelsSun2017 - predictive and interpretable models for PAMPA permeability 7
Parallel Artificial Membrane Permeability is an in vitro surrogate to determine the permeability of drugs across cellular membranes. PAMPA at pH 7.4 was experimentally determined in a dataset of 5,473 unique compounds by the NIH-NCATS. 50% of the dataset was used to train a classifier (SVM) to predi...
2024-04-23 | MODEL2404220001 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
ModelsMerget2013 - Mycobacterium tuberculosis permeability prediction tool
MycPermCheck predicts potential to permeate the Mycobacterium tuberculosis cell membrane based on physicochemical properties. Due to the lack of reliable experimental datapoints, the authors defined the training set using molecules that are active against M.tb. Model Type: Predictive machine learni...
2024-05-21 | MODEL2405210004 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
GenomicsPhysiological Vascular Permeability Requires Induction of Endothelial NR4A1 by Progesterone Receptor [ChIP-Seq]
Vascular permeability is frequently associated with inflammation and it is triggered by chemokines and by a cohort of secreted permeability factors, such as VEGF. In contrast, here we showed that the physiological vascular permeability that precedes implantation is directly controlled by progestero...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-43786 | biostudies-arrayexpress
TranscriptomicsPhysiological Vascular Permeability Requires Induction of Endothelial NR4A1 by Progesterone Receptor [RNA-Seq]
Vascular permeability is frequently associated with inflammation and it is triggered by chemokines and by a cohort of secreted permeability factors, such as VEGF. In contrast, here we showed that the physiological vascular permeability that precedes implantation is directly controlled by progestero...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-43788 | biostudies-arrayexpress
ModelsChi2019 - In Silico Prediction of PAMPA Effective Permeability Using a Two-QSAR Approach
The authors provide a dataset of 200 small molecules and their experimentally measured permeability in a PAMPA assay. Using this data, we have trained a model that predicts the logarithm of the effective permeability coefficient. Model Type: Predictive machine learning model. Model Relevance: Predi...
2024-06-03 | MODEL2406030003 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
ClinicalThe Effects of Probiotics on Intestinal Permeability in Gastrointestinal Cancer Patients in Chemotherapy
The aim of this study is to test the hypothesis that adjuvant administration of probiotics in cancer patients undergoing chemotherapy can reduce a chemo-induced increased intestinal permeability. Furthermore, we hypothesize that the use of probiotics may reduce the occurrence of gastrointestinal sid...
2286720 | ecrin-mdr-crc
Sort   by:  
 Page size