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TranscriptomicsA Myc transcriptional program that is independent of EMT drives a poor prognosis tumor-propagating phenotype in HER2+ breast cancer
The HER2 (ERBB2) and MYC genes are commonly amplified genes in breast cancer, yet little is known about their molecular and clinical interaction. Using a novel chimeric mammary transgenic approach and in vitro models, we demonstrate markedly increased self renewal and tumour propagating capability o...
ORGANISM(S): Homo sapiens 
2013-09-24 | E-GEOD-43730 | biostudies-arrayexpress
TranscriptomicsTumor Suppressor Role for the c-Myb Oncogene in Luminal Breast Cancer
The transcription factor c-Myb has been well characterized as an oncogene in several human tumor types, and its expression in the hematopoietic stem/progenitor cell population is essential for proper hematopoiesis. However, the role of c-Myb in mammopoeisis and breast tumorigenesis is poorly unders...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-21371 | biostudies-arrayexpress
TranscriptomicsMolecular portraits of human breast tumors
Set of 65 surgical specimens of human breast tumors from 42 different individuals, using complementary DNA microarrays representing 8,102 human genes. Gene expression variation patterns within this set provided a distinctive molecular portrait of each tumor. Twenty of the tumors were sampled twice, ...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-61 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast carcinoma tissues representing 930 patients with 17.4 years mean follow-up, basal cytokeratin expression was associated with decreased disease-specific survival
Expression profiling studies have classified breast carcinomas into luminal, normal breast-like, HER2 expressing and basal-like groups, with the latter two associated with poor outcomes. This study's objectives were to define an immunohistochemical profile that identifies basal-like tumors, to ident...
ORGANISM(S): Homo sapiens 
2006-09-15 | E-SMDB-2863 | biostudies-arrayexpress
UnknownPotential tumor suppressor role for the c-Myb oncogene in luminal breast cancer.
Not available
S-EPMC2951337 | biostudies-literature
TranscriptomicsHuman mammary epithelium and breast cancer
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. cDNA microarrays and a clustering algorithm were used to identify patterns of gene expression in human mammary epithelial cells growing in culture and in primary human breast tumors. Clusters of coexpressed ge...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-53 | biostudies-arrayexpress
UnknownTumor Suppressor Role for the c-Myb Oncogene in Luminal Breast Cancer
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-21371 | biostudies-other
TranscriptomicsRERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer
Using microarray analysis, we identified a unique ras superfamily gene, termed RERG (ras-related and estrogen-regulated growth inhibitor), whose expression was decreased or lost in a significant percentage of primary human breast tumors that show a poor clinical prognosis. Importantly, high RERG exp...
ORGANISM(S): Homo sapiens 
2005-07-23 | E-GEOD-2987 | biostudies-arrayexpress
TranscriptomicsMutant PI3K cooperates with HER2 to promote mammary tumor formation and induces trastuzumab resistance in vivo
HER2 (ERBB2) gene amplification and PIK3CA mutations often co-occur in breast cancer, and aberrant activation of the PI3K pathway has been implicated in resistance to HER2-directed therapies. We have created a mouse model of HER2-overexpressing (HER2+), PIK3CAH1047R-mutant breast cancer. Mice expres...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-41118 | biostudies-arrayexpress
Unknownc-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression.
Not available
S-EPMC4494910 | biostudies-literature
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