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MetabolomicsPEROXISOMAL-MITOCHONDRIAL INTERPLAY ALTERATIONS IN SKELETAL MUSCLE RESULT IN EARLY-ONSET SARCOPENIA

Adjustments in muscle mass and metabolic demand are crucial for regulating whole-body metabolism, locomotion, eating, and respiration. Therefore, skeletal muscle is a central influencer of several human diseases. Muscle dysfunction correlates with the onset and progression of several metabolic di...

2025-09-15 | MTBLS12833 | MetaboLights
MetabolomicsSequential lipidomic, metabolomic, and proteomic analyses of serum, liver, and heart tissue specimens from peroxisomal biogenesis factor 11α knockout mice
Peroxisomes are versatile single membrane-enclosed cytoplasmic organelles, involved in reactive oxygen species (ROS) and lipid metabolism and diverse other metabolic processes. Peroxisomal disorders result from mutations in Pex genes-encoded proteins named peroxins (PEX proteins) and single peroxiso...
2022-02-02 | MTBLS1887 | MetaboLights
ProteomicsThe yeast peroxisomal proteome at absolute quantitative scale
Peroxisomes are dynamic organelles vital for lipid metabolism and redox homeostasis. In Saccharomyces cerevisiae, the expression of peroxisomal proteins is tightly regulated in response to metabolic conditions. Here, we provide the first absolute quantification of the yeast peroxisomal proteome unde...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-02-16 | PXD069526 | Pride
Saccharomyces cerevisiae  peroxisomes  protein copy numbers  absolute quantification  proteomic ruler  mass spectrometry 
ProteomicsSystems-level organisation of yeast methylotrophic lifestyle - organelle preparation
Changes in the proteome of Pichia pastoris cultures either grown on glucose or methanol were analysed using a 2D-chromatography based TMT labeling LC-ESI-MS workflow. Three biological replicates, with two technical replicates each, had been analyzed leading to six replicate data sets of both growth ...
ORGANISM(S): Komagataella pastoris DSMZ 70382 
2015-10-01 | PXD002831 | Pride
Lc-esi-ms Peroxisomal preparation 
ProteomicsPex39 facilitates peroxisomal import of PTS2 proteins – PEX39 KO SILAC data
Peroxisomes are metabolic organelles essential for human health. Defects in peroxisomal biogenesis proteins (peroxins/PEXs) cause devastating disease. PEX7 binds cargo proteins containing a type 2 peroxisomal targeting sequence (PTS2) to enable import of PTS2 proteins from the cytosol into peroxisom...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-07 | PXD051550 | Pride
Quantitative mass spectrometry Peroxisomes Silac Saccharomyces cerevisiae Peroxisomal matrix protein import Pts2 import Pex39 
ProteomicsPex39 facilitates peroxisomal import of PTS2 proteins – ScPex18 AP-MS data
Peroxisomes are metabolic organelles essential for human health. Defects in peroxisomal biogenesis proteins (peroxins/PEXs) cause devastating disease. PEX7 binds cargo proteins containing a type 2 peroxisomal targeting sequence (PTS2) to enable import of PTS2 proteins from the cytosol into peroxisom...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-07 | PXD051501 | Pride
Peroxisomes Affinity purification-mass spectrometry Label free quantification Saccharomyces cerevisiae Peroxisomal matrix protein import Pts2 import Pex39 
TranscriptomicsTranscription profiling of Arabidopsis peroxisomal mdh mutant
The aim is to study the function of peroxisomal NAD-malate dehydrogenase in fatty acid beta-oxidation, glyoxylate cycle and photorespiration. Both peroxisomal MDH genes (At2g22780 and At5g09660) have been knocked out with T-DNA insertions and a double mutant made. Double mutant seedlings are blocked...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-5641 | biostudies-arrayexpress
ProteomicsThe Hansenula polymorpha Mitochondrial Carrier Family protein Mir1 is dually localized at peroxisomes and mitochondria
Peroxisomes are ubiquitous cell organelles involved in various metabolic pathways. In order to properly function, several cofactors, substrates and products of peroxisomal enzymes need to pass the organellar membrane. So far only a few transporter proteins have been identified. We analysed peroxisom...
ORGANISM(S): Hansenula polymorpha vector pAM619 
2024-05-10 | PXD050324 | Pride
Mitochondrial carrier family Peroxisomes Mitochondria Transporter proteins Mir1 Dual localization 
ProteomicsStructure of Pex8 in complex with peroxisomal receptor Pex5 reveals its essential role in peroxisomal cargo translocationSMS
Please provide an overall description of your study, think something similar in scope to the manuscript abstractPeroxisomes are essential cellular organelles that enable the sequestered execution of a broad range of metabolic processes. Due to the lack of an internal protein synthesis machinery, the...
ORGANISM(S): Komagataella phaffii 
2026-04-17 | PXD076857 | Pride
MetabolomicsIntegrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism

OCIAD1 (Ovarian Cancer Immunoreactive Antigen Domain Containing 1) is a membrane protein largely localized to mitochondria, however, its function in health or disease is not well understood. To comprehensively characterize the molecular changes upon lack of OCIAD1, we used mass spectrometry to st...

2025-04-25 | MTBLS12329 | MetaboLights
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