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ProteomicsDrosophila S2R+ / TSC1 / TSC2 mutant phosphoproteomics
The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a point of convergence for major cell signaling pathways that regulate mTOR complex 1 (mTORC1). Mutation or aberrant inhibition of the TSC complex...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-10-24 | PXD002670 | Pride
Tsc2 Drosophila Tsc1 Phosphoproteomics 
TranscriptomicsIn vivo transcriptional activation using CRISPR-Cas9 in Drosophila
Identifying putative transcription factor target genes by combining CRISPR/Cas9-based transcriptional activation with RNAseq in Drosophila S2R+ cells. This study focuses on the transcription factors Twist and Snail, singly and together. RNA from Drosophila cells following CRISPR/Cas9-based activatio...
ORGANISM(S): Drosophila melanogaster 
2015-08-10 | E-GEOD-71430 | biostudies-arrayexpress
ProteomicsProteomics of Protein Trafficking by In vivo Tissue Specific Labeling
Drosophila Hemolymph Mass spectrometry proteomics Data Instrument: Thermo Fisher Scientific high resolution hybrid Orbitrap XL mass spectrometer; samples delivered by nano electrospray at 300 nL/min with a Thermo Fisher Scientific EASY-nLCII HPLC with a 75 um diameter x 10 cm length C18 column. Data...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2020-10-15 | MSV000086291 | MassIVE
ProteomicsA genetic model for in vivo proximity labeling of the mammalian secretome
Yang R, Meyer AS, Droujinine I, Udeshi ND, Hu Y, Guo J, McMahon J, Carey DK, Xu C, Qiao F, Sha J, Qin S, Rocco D, Wohlschlegel J, Ting AY, Carr SA, Perrimon N, McMahon AP. 2022. Organ functions are highly specialized and interdependent. Tissue-specific secreted factors play a critical role in organ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-02-16 | MSV000088848 | MassIVE
TranscriptomicsProcessing of Drosophila endo-siRNAs depends on a specific Loquacious isoform
Drosophila melanogaster expresses three classes of small RNAs, which are classified according to their mechanisms of biogenesis. MicroRNAs are ~22-23-nt, ubiquitously expressed small RNAs that are sequentially processed from hairpin-like precursors by Drosha/Pasha and Dcr-1/Loquacious complexes. Mic...
ORGANISM(S): Drosophila melanogaster 
2009-07-30 | E-GEOD-17171 | biostudies-arrayexpress
TranscriptomicsHierarchical rules for Argonaute loading in Drosophila
Drosophila Argonaute-1 and Argonaute-2 differ in function and small RNA content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by microRNAs. microRNA duplexes are intrinsically asymmetric, with one strand, the miR strand, preferentially entering AGO1 to recognize and regulate the...
ORGANISM(S): Drosophila melanogaster 
2009-11-15 | E-GEOD-17734 | biostudies-arrayexpress
TranscriptomicsSystems Modeling of the Rho Signaling Network
Describing the architecture of robust, nonlinear cell signaling networks is essential to gain a predictive understanding of cellular behavior. The structure of the Drosophila Rho-signaling network, comprised of Rho-family GTPases, RhoGTP Exchange Factors (RhoGEFs), and RhoGTPase Activating Proteins...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-18307 | biostudies-arrayexpress
TranscriptomicsExpression data from skeletal muscles of flies with muscle-specific overexpression of Foxo or Mnt
Skeletal muscle senescence influences whole organism aging, yet little is known on the relay of pro-longevity signals from muscles to other tissues. We performed an RNAi screen in Drosophila for muscle-released cytokines ('myokines') regulating lifespan and identified Myoglianin, the homolog of huma...
ORGANISM(S): Drosophila melanogaster 
2014-07-02 | E-GEOD-39877 | biostudies-arrayexpress
ProteomicsProteome of Yki-driven intestinal stem cell tumors in Drosophila midgut
The experiment was undertaken to characterize Yki-driven intestinal stem cell tumor proteome from Drosophila adult midguts, and to identify changes in the ISC tumor proteome in flies fed on TONDU peptide, using LC MS/MS approach. esgts>UAS-yki3SA flies on day 1, day 7 of tumor induction; TONDU-pepti...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2020-01-25 | MSV000084841 | MassIVE
TranscriptomicsA genome-scale shRNA resource for transgenic RNAi in Drosophila
Existing transgenic RNAi resources in Drosophila utilize the expression of long double stranded hairpin RNAs and are powerful tools for the identification and characterization of genes involved in various processes. However, they are ineffective to knockdown genes during oogenesis, an important mode...
ORGANISM(S): Drosophila melanogaster 
2011-03-26 | E-GEOD-27039 | biostudies-arrayexpress
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