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TranscriptomicsEstrogen and mTORC1 dependent genes in the uterus of uterine-specific Tsc2-null mice
To uncover genes regulated by mTORC1 and estradiol in uterine Tsc2-null LAM like cells, we performed RNAseq on uteri from 12-week old wild-type (WT) and uterine-specific Tsc2-null (KO) mice that were either untreated (intact), oopherectomized (ovx) or oopherectomized + treated with 17β-estradiol pe...
ORGANISM(S): Mus musculus 
2016-02-26 | E-GEOD-78701 | biostudies-arrayexpress
TranscriptomicsEvidence that TSC2 acts as a transcription factor and binds to and represses the promoter of Epiregulin
In order to identify the genes regulated by TSC2, gene expression profiling of two clones stably overexpressing TSC2 was performed. The gene expression profiles of two stable transfectant clones overexpressing the full-length TSC2 in KB cells were compared with the gene expression profile of a vecto...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-52061 | biostudies-arrayexpress
ProteomicsDrosophila S2R+ / TSC1 / TSC2 mutant phosphoproteomics
The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a point of convergence for major cell signaling pathways that regulate mTOR complex 1 (mTORC1). Mutation or aberrant inhibition of the TSC complex...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-10-24 | PXD002670 | Pride
Tsc2 Drosophila Tsc1 Phosphoproteomics 
TranscriptomicsRapamycin effect on Wild Type and TSC deficient Mouse Embryonic Fibroblasts : Time Course
Aberrant activation of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is a common molecular event in a large variety of pathological settings, including genetic tumor syndromes, cancer, and obesity. However, the cell intrinsic consequences of mTORC1 activation remain poorly defined. He...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21755 | biostudies-arrayexpress
TranscriptomicsRNA-seq of depdc5-/-, tsc2-/-, depdc5-/- x tsc2-/- and wildtype zebrafish larvae
Transcriptome analysis of the heads of 5 dpf epdc5-/-, tsc2-/-, depdc5-/- x tsc2-/- and wildtype zebrafish larvae to provide insights into the neuropathological processes underlying the observed epileptic phenotype in sv2a-/- zebrafish larvae.
ORGANISM(S): Danio rerio 
2022-09-12 | E-MTAB-11776 | biostudies-arrayexpress
GenomicsTsc2 coordinates differentiation
Tsc2 coordinates differentiation
PRJNA953947 | ENA
GenomicsRNA-seq of depdc5-/-, tsc2-/-, depdc5-/- x tsc2-/- and wildtype zebrafish larvae
RNA-seq of depdc5-/-, tsc2-/-, depdc5-/- x tsc2-/- and wildtype zebrafish larvae
PRJEB53153 | ENA
GenomicsTsc2 coordinates differentiation [scRNA-seq]
Tsc2 coordinates differentiation [scRNA-seq]
PRJNA954867 | ENA
GenomicsTsc2 coordinates differentiation [bulkRNA-seq]
Tsc2 coordinates differentiation [bulkRNA-seq]
PRJNA954865 | ENA
TranscriptomicsInitiation Pausing of 80S Ribosome on mRNA Is Governed by 5’UTR and Responsive to mTORC1 Signaling (Microarray)
Recent studies have revealed that the mRNA translation is punctuated by ribosomal pauses through the body of transcripts. However, little is known about its physiological significance and regulatory aspects. Here we present a multi-dimensional ribosome profiling approach to quantify the dynamics o...
ORGANISM(S): Mus musculus 
2011-11-12 | E-GEOD-25331 | biostudies-arrayexpress
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