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MetabolomicsArginine-induced metabolomic perturbation in Streptococcus mutans

BACKGROUND: Streptococcus mutans is a major pathogen responsible for dental caries. Arginine is a promising potential caries preventive agent which can inhibit the growth of S. mutans. However, the mechanism whereby arginine inhibits S. mutans growth r...

2023-10-20 | MTBLS3020 | MetaboLights
MetabolomicsDeciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study

BACKGROUND: Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic ...

2021-08-03 | MTBLS981 | MetaboLights
MetabolomicsUrinary metabolomics reveals kynurenine pathway perturbation in newborns with transposition of great arteries after surgical repair

INTRODUCTION: Transposition of the great arteries (TGA) is a cyanotic congenital heart defect that requires surgical correction, with the use of cardiopulmonary-bypass (CPB), usually within 3 weeks of life. The use of CPB in open heart surgery results in brain hypoperfu...

2020-04-15 | MTBLS946 | MetaboLights
TranscriptomicsNetwork Perturbation Amplitude on NHBE cells
High-throughput measurement technologies produce data sets that have the potential to elucidate the biological impact of disease, drug treatment, and environmental agents on humans. The scientific community faces an ongoing challenge in the analysis of these rich data sources to more accurately char...
ORGANISM(S): Rattus norvegicus 
2012-12-15 | E-MTAB-1311 | biostudies-arrayexpress
MetabolomicsIntestinal Microbe-Metabolite Network Associated with The Efficacy of Fecal Microbiota Transplantation Therapy in Inflammatory Bowel Disease

BACKGROUND: Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is a type of recurrent and incurable disease, which can lead to the loss of workability, increase cancer risk and bring serious economic burden to patients. Abnormal intestin...

2026-03-11 | MTBLS3909 | MetaboLights
TranscriptomicsNetwork Perturbation Amplitude on NHBE cells
High-throughput measurement technologies produce data sets that have the potential to elucidate the biological impact of disease, drug treatment, and environmental agents on humans. The scientific community faces an ongoing challenge in the analysis of these rich data sources to more accurately char...
ORGANISM(S): Homo sapiens 
2012-04-15 | E-MTAB-1027 | biostudies-arrayexpress
TranscriptomicsPharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis
The search for developmental mechanisms driving vertebrate organogenesis has paved the way toward a deeper understanding of birth defects. During embryogenesis, parts of the heart and craniofacial muscles arise from pharyngeal mesoderm (PM) progenitors. Here, we reveal a hierarchical regulatory netw...
ORGANISM(S): Mus musculus 
2012-11-26 | E-GEOD-42389 | biostudies-arrayexpress
MetabolomicsDisturbed Microbiota-Metabolites-Immune Interaction Network is Associated with Olfactory Dysfunction in Patients with Chronic Rhinosinusitis

PURPOSE: Olfactory dysfunction (OD) is a debilitating symptom frequently reported by patients with chronic rhinosinusitis (CRS) and it is associated with a dysregulated sinonasal inflammation. However, little information is available about the effect of the inflammation-related n...

2023-05-12 | MTBLS7584 | MetaboLights
TranscriptomicsHost Regulatory Network Response to Infection with Highly Pathogenic H5N1 Avian Influenza Virus
Over the last decade, more than half of humans infected with highly pathogenic avian influenza (HPAI) H5N1 viruses have died, and yet virus-induced host signaling has yet to be clearly elucidated. Airway epithelia are known to produce inflammatory mediators that contribute to HPAI H5N1-mediated pat...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-GEOD-28166 | biostudies-arrayexpress
ProteomicsMultilevel Omics-Readouts of Perturbation Studies in vitro are Determined by Memory Effects from Subculture
Mass spectrometry-based omics technologies are of increasing relevance for drug discovery. In order to map drug treatments to biological pathways for mode of action (MoA) deconvolution, they rely on the determination of multiple testing corrected significant molecular events. The main contributors t...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD051069 | Pride
Phosphoproteomics Reproducibility Multi-level omics Subculture Arsenic trioxide Mode of action deconvolution Proteomics Perturbation network Eicosadomics 
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