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TranscriptomicsComparative genomic hybridization of human patient reveals association of hereditary thrombocythemia and distal limb defects with a thrombopoietin gene mutation
Array-Comparative Genomic Hybridization (CGH) was performed using a whole-genome microarray with a resolution of about 75 Kb on a man showing unilateral congenital transverse defect of his right upper (absence of forearm and hand) and right lower (absence of foot) limbs. He had also a high platelet ...
ORGANISM(S): Homo sapiens 
2009-06-17 | E-MEXP-2214 | biostudies-arrayexpress
TranscriptomicsInhibition of MYCN by a PNA anti-gene in alveolar rhabdomyosarcoma
The objective was to identify the molecular mechanisms responsible for in vitro and in vivo efficacy of an anti-MYCN peptide nucleic acid on a preclinical model of alveolar rhabdomyosarcoma. Cells treated with a anti-MYCN PNA exhibit growth arrest and apoptosis, and in vivo tumor growth is blocked. ...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-7959 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cultured rat cardiomyocytes grown with eicosapentaenoic acid or docosahexaenoic acid supplementation in the culture media
Despite the recognized protective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in cardiovascular diseases, and the demonstration of the control of gene expression by polyunsaturated fatty acids (PUFAs), the effects of these n-3 fatty acids on the whole genoma has never been ...
ORGANISM(S): Rattus norvegicus 
2008-05-07 | E-GEOD-4327 | biostudies-arrayexpress
UnknownOff-label use of combined antiretroviral therapy, analysis of data collected by the Italian Register for HIV-1 infection in paediatrics in a large cohort of children.
Not available
S-EPMC8760752 | biostudies-literature
TranscriptomicsMLL partner genes confer distinct biological and clinical signatures of pediatric AML, an AIEOP study
We retrospectively analyzed AML patients enrolled in the AIEOP since 2000, 42 patients with 11q23 rearrangement were analyzed by gene expression profile Gene expression analyses were performed to compare AML MLL partner genes (AF9, AF10, AF6, ENL, ELL, Septin 6, and AF1q) Keywords: Expression data ...
ORGANISM(S): Homo sapiens 
2011-04-21 | E-GEOD-19577 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in neuroblastoma cells upon CHAF1A silencing
We used an inducible ShRNA system and microarrays to detail the global programme of gene expression underlying neuroblastoma differentiation upon CHAF1A silencing . CHAF1A is a subunit of the Chromatin Assembly Factor-1 (CAF1) and regulates H3K9-trimethylation. High expression of CHAF1A strongly cor...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-51978 | biostudies-arrayexpress
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