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MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
ProteomicsComparative quantitative LC-MS/MS analysis of 13 amylase/trypsin inhibitors in ancient and modern Triticum species
Amylase/trypsin inhibitors (ATIs) are major wheat allergens and they are also implicated in causing non-celiac gluten sensitivity and worsening other inflammatory conditions. With only few studies on ATI contents in different Triticum species available so far, we developed a targeted liquid chromato...
ORGANISM(S): Triticum 
2021-03-12 | PXD020714 | panorama
TranscriptomicsEndogenous expression of an oncogenic PI3K mutation leads to activated PI3K pathway signaling and an invasive phenotype
The PTEN/PI3K pathway is commonly mutated in cancer and therefore represents a rational target for therapeutic intervention. In order to investigate the primary phenotype(s) mediated by mutant PIK3CA in a clean and highly patient-relevant context, we utilized a non-tumorigenic MCF10A parental and is...
ORGANISM(S): Homo sapiens 
2011-08-09 | E-GEOD-17785 | biostudies-arrayexpress
TranscriptomicsGlucosylated hydroxymethyluracil (DNA base J) prevents transcriptional read-through in Leishmania
Some T's in nuclear DNA of trypanosomes and Leishmania are hydroxylated and glucosylated to yield base J (?-D-glucosyl-hydroxymethyluracil). In Leishmania about 99% of J is located in telomeric repeats. We show here that most of the remaining J is located at chromosome-internal RNA Polymerase II ter...
ORGANISM(S): Leishmania major 
2011-10-15 | E-GEOD-32976 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of synovial tissue biopsies from individuals with rheumatoid arthritis from the STRAP randomised clinical trial
Transcriptomic profiles of synovial biopsies of rheumatoid arthritis (RA) patients recruited into the STRAP randomised clinical trial: RNA-Seq data from 210 patients at baseline. Patients were randomly assigned to etanercept, tocilizumab and rituximab. For the full study protocol and baseline patien...
ORGANISM(S): Homo sapiens 
2025-04-28 | E-MTAB-13733 | biostudies-arrayexpress
GenomicsLinking genes, genomic instability and molecular subgroups in medulloblastoma
Brain tumors are the second most common pediatric cancer and carry the highest mortality rates in this age group. Medulloblastoma is the most frequent malignant brain tumor of childhood. Recent studies indicate that medulloblastoma comprises at least four sub-entities (SHH-signaling, WNT-signali...
EGAS00001000085 | EGA
GenomicsEGAS00000000046-ega-20110530 - samples
ICGC Germany PedBrain Medulloblastoma Pilot_2_LM
EGAD00001000027 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-24-09-2015-14:57:59:343-450 - samples
release_2: ICGC PedBrain: whole exome sequencing and Target-Seq
EGAD00001001624 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-24-09-2015-12:58:34:639-433 - samples
release_2: ICGC PedBrain: RNA sequencing
EGAD00001001620 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-25-01-2016-08:42:37:641-84 - samples
Whole genome bisulfite sequencing of pedbrain - medulloblastoma
EGAD00001001891 | EGA
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