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TranscriptomicsExploring the role of sigma factor gene expression on production by Corynebacterium glutamicum: sigma factor H and FMN as example
Bacteria are known to cope with environmental changes by using alternative sigma factors binding to RNA polymerase core enzyme. Sigma factor is one of the targets to modify transcription regulation in bacteria and to influence production capacities. In this study, the effect of overexpressing all an...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2015-06-20 | E-GEOD-70017 | biostudies-arrayexpress
UnknownGenetically regulated gene expression and proteins revealed discordant effects.
Not available
S-EPMC9126407 | biostudies-literature
TranscriptomicsAldh1b1 controlled timing of pancreas specification is important for β cell functionality and glucose homeostasis in the adult.
Maintenance of normal glucose homeostasis is disturbed in diabetes. In the β cell, this involves a glucose sensor converting increased glucose levels to insulin secretion. Understanding the developmental regulatory networks that define a fully functional β cell is important for elucidating the genet...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-58025 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rats treated with nandrolone with denervation
We showed that nandrolone attenuated subacute, but not acute, denervation atrophy and upregulation of MAFbx. The present study explored the molecular determinants for this time-dependent effect using microarray analysis to identify genes that were differentially regulated by administration of nandro...
ORGANISM(S): Rattus norvegicus 
2009-09-11 | E-GEOD-17959 | biostudies-arrayexpress
TranscriptomicsIL-10 from intestinal macrophages prevents excessive innate immune responses to bacteria by limiting IL-23 synthesis
Innate immune responses must be regulated in the intestine to prevent excessive inflammation. Here, using gene reporter mice, we show that a subset of mouse colonic macrophages constitutively produced the anti-inflammatory cytokine IL-10. In mice infected with Citrobacter rodentium, which is consid...
ORGANISM(S): Mus musculus 
2015-05-12 | E-GEOD-58677 | biostudies-arrayexpress
TranscriptomicsHuman-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
The evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Here, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a novel approach from developi...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-65000 | biostudies-arrayexpress
TranscriptomicsDEFINING A RAT BLOOD PRESSURE QUANTITATIVE TRAIT LOCUS TO A <81.8KB CONGENIC SEGMENT: COMPREHENSIVE SEQUENCING AND RENAL TRANSCRIPTOME ANALYSIS.
Evidence from multiple linkage and genome-wide association studies suggest that human chromosome 2 (HSA2) contains alleles that influence blood pressure (BP). Homologous to a large segment of HSA2 is rat chromosome 9 (RNO9), to which a BP quantitative trait locus (QTL) was previously mapped. The obj...
ORGANISM(S): Rattus norvegicus 
2010-07-15 | E-GEOD-22515 | biostudies-arrayexpress
TranscriptomicsExpression data from wild type and ttk^twk mutant whole ovaries
Epithelial tube morphogenesis requires precise orchestration of cell signaling, shape, migration, and adhesion. Follicle cells in the Drosophila ovary form epithelial tubes, the lumens of which act as molds for the eggshell respiratory filaments, or dorsal appendages (DAs). The Tramtrack69 (TTK69...
ORGANISM(S): Drosophila melanogaster 
2012-12-06 | E-GEOD-42758 | biostudies-arrayexpress
TranscriptomicsSkeletal Muscle Contraction Reduces Effects of Unloading on Bone Independently from the Central Nervous System: Studies Using Functional Electrical Stimulation after Spinal Cord Transection
Spinal cord injury (SCI) causes severe bone loss and disrupts connections between higher centers in the central nervous system (CNS) and bone. Muscle contraction elicited by functional electrical stimulation (FES) partially protects against loss of bone but cellular and molecular events by which th...
ORGANISM(S): Rattus norvegicus 
2012-06-27 | E-GEOD-30301 | biostudies-arrayexpress
UnknownGenome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.
Not available
S-EPMC8748632 | biostudies-literature
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