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TranscriptomicsMicroRNAs Regulate p21Waf1/Cip1 Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells
Studies of human embryonic stem cells (hESCs) commonly describe the non-functional p53-p21 axis of the G1/S checkpoint pathway with subsequent relevance for cell cycle regulation and the DNA damage response (DDR). Importantly, p21 mRNA is clearly present and upregulated after the DDR in hESCs but p2...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-36615 | biostudies-arrayexpress
ProteomicsStructural aspects of FOXO4 binding to DAF16 investigated with FPOP using both bottom-up and top-down MS.
A combination of covalent labelling techniques and mass spectrometry (MS) is currently a progressive approach for the de-riving insights relating to the mapping of protein surfaces or protein-ligand interactions. In this study, we mapped an interac-tion interface between DNA binding domain (DBD) of ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD027624 | Pride
Bottom-up proteomics Dna Transcription factors Protein Foxo4 Fast photochemical oxidation of proteins Top-dow proteomics 
ProteomicsCOX6B1 secures a redox-sensitive step in early cytochrome c oxidase assembly
COX6B is one of the eleven nuclear-encoded subunits of the human mitochondrial inner-membrane cytochrome c oxidase (cIV), which is located in the intermembrane space-facing region of cIV. In mammals, there are two COX6B isoforms: the ubiquitous isoform COX6B1, expressed in all cell types and tissues...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD061621 | Pride
Mitochondria Alternative oxidase (aox) Cytochrome c oxidase Respiratory chain biogenesis 
ProteomicsData-Independent Acquisition Represents a Promising Alternative for Fast Photochemical Oxidation of Proteins (FPOP) Samples Analysis
We propose a novel approach for FPOP data analysis, utilizing DIA data. The HbHp protein complex was analyzed by FPOP and measured on timsToF SCP in DIA, DDA and MS modes. The IDs of modified peptides were quantified for each acquisition mode and the extent of modification was calculated on the leve...
ORGANISM(S): Homo sapiens (Human) 
2024-07-08 | PXD050132 | Pride
Fast photochemical oxidation of proteins (fpop) Protein structure Protein footprinting Spectral library Hemoglobin-haptoglobin Data-independent acquisition (dia) 
ProteomicsCOX6B1 secures a redox-sensitive step in early cytochrome c oxidase assembly
COX6B is one of the eleven nuclear-encoded subunits of the human mitochondrial inner-membrane cytochrome c oxidase (cIV), which is located in the intermembrane space-facing region of cIV. In mammals, there are two COX6B isoforms: the ubiquitous isoform COX6B1, expressed in all cell types and tissues...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD061618 | Pride
Mitochondria Alternative oxidase (aox) Cytochrome c oxidase Respiratory chain biogenesis Complexome profiling 
TranscriptomicsDipeptidyl peptidase-IV is associated with decreased glioma growth
Effect of expression of dipeptidyl peptidase-IV (DPP-IV) in U373 cell line on uncontrolled cell proliferation and aberrant interactions with the brain extracellular matrix.
ORGANISM(S): Homo sapiens 
2011-12-31 | E-MTAB-583 | biostudies-arrayexpress
ProteomicsMolecular structure of blue laccase BP76, a unique termite suicidal defense weapon
Aging workers of the termite Neocapritermes taracua can defend their colony by sacrificing themselves by body rupture, mixing the externally stored blue laccase BP76 with hydroquinones to produce a sticky liquid rich in toxic benzoquinones. The study elucidates structure of BP76 isolated from N. tar...
ORGANISM(S): Neocapritermes taracua 
2025-03-13 | PXD053642 | Pride
Benzoquinone Insect glycosylation Protein stabilization Laccase Colony defence Mass spectrometry Autothysis Neocapritermes taracua Timstof scp 
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