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GenomicsAKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KD-rTSC]
AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KD-rTSC]
PRJNA847913 | ENA
GenomicsAKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KO-JZ]
AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KO-JZ]
PRJNA847912 | ENA
TranscriptomicsTranscription profiling of human embryonic kidney cell line HEK293T to investigate the effects of overexpression of FoxO4 or mutated FoxO4 in presence or absence of p300
Effects of overexpression of FoxO4 or mutated FoxO4 in presence or absence of p300 overexpression
ORGANISM(S): Homo sapiens 
2009-07-30 | E-MTAB-4 | biostudies-arrayexpress
ProteomicsStructural proteomics based investigation of DNA binding domain (DBD) of FOXO4 transcription factor in complex with DNA binding element (DNA)
The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level. We implemented a concerted structural proteomics approach, which ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2020-05-26 | PXD013969 | Pride
Hydrogen-deuterium exchange Transplatinum Cross-linking Protein Dna 
GenomicsGene expression profiles of FoxO4 overexpressing TH1 cells.
Gene expression profiles of FoxO4 overexpressing TH1 cells.
PRJNA549722 | ENA
ProteomicsMultiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function
Transcription factors harbour defined intrinsically disordered regulatory regions, which raises the question of how they mediate binding to structured co-regulators and how this regulates activity. Here, we present a detailed molecular regulatory mechanism of Forkhead box O4 (FOXO4) by the structure...
ORGANISM(S): Homo sapiens (Human) 
2022-04-15 | PXD026263 | Pride
Foxo signalling Post-translational modification Icat Structural biology Intrinsically disordered proteins Nmr spectroscopy Transcription factors Wnt signalling -catenin Phosphorylation 
ProteomicsThe Isotopic Depletion Increases the Spatial Resolution of FPOP Top-Down Analysis.
Protein radical labeling offers an alternative analytical method for probing protein structure or protein interaction with other bio-molecules. Since the Fast Photochemical Oxidation of Proteins has already shown its essential role in studying biomolecular as-semblies and it was successfully adopted...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044447 | Pride
Protein isotope depletion Ire Fast photochemical oxidation of proteins Mass spectrometry Insulin response element Top-down Foxo4 Electron-capture dissociation Multicasi. 
ProteomicsStructural aspects of FOXO4 binding to DAF16 investigated with FPOP using both bottom-up and top-down MS.
A combination of covalent labelling techniques and mass spectrometry (MS) is currently a progressive approach for the de-riving insights relating to the mapping of protein surfaces or protein-ligand interactions. In this study, we mapped an interac-tion interface between DNA binding domain (DBD) of ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD027624 | Pride
Bottom-up proteomics Dna Transcription factors Protein Foxo4 Fast photochemical oxidation of proteins Top-dow proteomics 
TranscriptomicsAKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KO-JZ]
AKT1 is a serine/threonine kinase implicated in fetal, placental, and postnatal growth. In this study, we investigated roles for AKT1 in placental development using a genome-edited/loss-of-function rat model. Both heterozygous and homozygous Akt1 mutant rats were viable and fertile. Disruption of AK...
ORGANISM(S): Rattus norvegicus 
2023-01-05 | GSE205829 | GEO
TranscriptomicsAKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KD-rTSC]
AKT1 is a serine/threonine kinase implicated in fetal, placental, and postnatal growth. In this study, we investigated roles for AKT1 in placental development using a genome-edited/loss-of-function rat model. Both heterozygous and homozygous Akt1 mutant rats were viable and fertile. Disruption of AK...
ORGANISM(S): Rattus norvegicus 
2023-01-05 | GSE205828 | GEO
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