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UnknownRetained platinum uptake and indifference to p53 status make novel transplatinum agents active in platinum-resistant cells compared to cisplatin and oxaliplatin.
Not available
S-EPMC3679288 | biostudies-literature
UnknownG-quadruplex inducer/stabilizer pyridostatin targets SUB1 to promote cytotoxicity of a transplatinum complex.
Not available
S-EPMC8989551 | biostudies-literature
UnknownConformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)].
Not available
S-EPMC1258167 | biostudies-literature
UnknownSynthesis, Characterization and Antiproliferative Evaluation of Pt(II) and Pd(II) Complexes with a Thiazine-Pyridine Derivative Ligand.
Not available
S-EPMC8143583 | biostudies-literature
ProteomicsStructural proteomics based investigation of DNA binding domain (DBD) of FOXO4 transcription factor in complex with DNA binding element (DNA)
The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level. We implemented a concerted structural proteomics approach, which ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2020-05-26 | PXD013969 | Pride
Hydrogen-deuterium exchange Transplatinum Cross-linking Protein Dna 
ProteomicsDifferential proteomics of HeLa cells treated with PDS for 24 hours and untreated HeLa cells
Pyridostatin (PDS) is a well-known G-quadruplex (G4) inducer and stabilizer, yet its target genes have remained unclear. Herein, combining mass spectrometry based proteomics strategy with bioinformatics analysis, we revealed that PDS significantly downregulated 22 proteins, of which the genes contai...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD029521 | Pride
Hela Lc-ms/ms 
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